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Archived Comments for: Recurrence dynamics does not depend on the recurrence site

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  1. Bi-Modal Hazard (BMH) an epidemiological hallmark of cancer

    Gershom Zajicek, Hebrew University of Jerusalem

    13 November 2008

    The phenomenon described by the authors is known as bi-modal hazard rate (BMH).In an detailed analysis based of SEER data I have shown that hazard rate in breast cancer proceeds through three phases. Following diagnosis and treatment hazard rate rises (AB). By the third year it reaches its maximum whereupon it declines to a minimum (BC). from there and on it gradually rises to a second maximum whereupon the patient dies (CD). This pattern appears in many cancers and is unique to cancer and does not appear in other chronic diseases. It is an epidemiological hallmark of cancer. It is so typical of cancer that it distinguishes cancer from other chronic diseases.

    Data source: Surveillance, Epidemiology, and End Results (SEER) Program ( SEER*Stat Database: Incidence - SEER 9 Regs Public-Use, Nov 2004 Sub (1973-2002), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2005, based on the November 2004 submission.

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    Competing interests

    None declared