Gene products of chromosome 11q and their association with CCND1gene amplification and tamoxifen resistance in premenopausal breast cancer

Table 1 Fraction of tumors showing CCND1 amplification (FISH) in subgroups defined by expression of the 11q proteins

	Cortactin	FADD	Cyclin D₁	Pak1	Chk1 fraction positive nuclei (%)			Chk1/Ki67 ratio
					0 to 5	6 to 50	51 to 100	Deviant	Normal
CCND1 amplified (%)	14.6	12.6	15.9	16.3	24.2	15.3	0	34.8	14.8
Amplified and overexpessing (%)	44.0	41.7	31.8	28.9
P value	0.020	0.002	<0.001	0.008	0.010			0.034

P values for correlations between expression of the 11q gene products and CCND1 amplification are indicated in the bottom row. Chk1, checkpoint kinase 1; FADD, Fas-associated death domain; FISH, fluorescence in situ hybridization; Pak1, p21-activated kinase 1.

ISSN: 1465-542X