Table 2 Incidence of grade 3 to grade 4 hematologic toxicity, per age interval and per taxane

Leukopenia

   Patients aged < 60 years

1,534 (59.6)

196 (35.3)

1,730 (55.3)

<0.001

   Patients aged 60 to 64 years

351 (68.3)

55 (45.8)

406 (64.0)

<0.001

   Patients aged > 64 years

234 (69.2)

38 (49.4)

272 (65.5)

0.001

   P value

<0.001

0.011

<0.001

Neutropenia

   Patients aged < 60 years

926 (47.4)

226 (44.8)

1,152 (46.9)

0.321

   Patients aged 60 to 64 years

273 (57.6)

53 (48.6)

326 (55.9)

0.111

   Patients aged > 64 years

190 (59.2)

35 (49.3)

225 (57.4)

0.164

   P value

<0.001

0.643

<0.001

Febrile neutropenia

   Patients aged <60 years

179 (7.2)

2 (0.4)

181 (6.1)

<0.001

   Patients aged 60 to 64 years

40 (8.1)

3 (2.8)

43 (7.2)

0.085

   Patients aged > 64 years

28 (8.7)

1 (1.4)

29 (7.4)

0.061

   P value

0.560

0.049

0.430

Anemia

   Patients aged < 60 years

57 (2.2)

40 (7.2)

97 (3.1)

<0.001

   Patients aged 60 to 64 years

12 (2.3)

4 (3.3)

16 (2.5)

0.756

   Patients aged > 64 years

12 (3.6)

2 (2.6)

14 (3.4)

0.946

   P value

0.315

0.110

0.674

Thrombopenia

   Patients aged < 60 years

44 (1.7)

26 (4.7)

70 (2.3)

<0.001

   Patients aged 60 to 64 years

13 (2.5)

1 (0.8)

14 (2.2)

0.432

   Patients aged > 64 years

21 (6.2)

0 (0.0)

21 (5.1)

0.050

   P value

<0.001

0.025

0002