Figure 4
High p16INK4a mRNA and protein levels are associated with retinoblastoma (RB) 1 loss of heterozygosity (LOH). (a) RB1 staining of normal breast tissue, (b) RB1 LOH+ basal-like tumour lacking RB1 staining, and (c) the same RB1 LOH+ basal-like tumour showing staining for p16INK4a both nuclear and cytoplasmic.(d) Box plot comparison showing high p16INK4a mRNA expression in RB1 LOH + breast tumours.