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Table 4 Frequency of molecular phenotypes among DCIS and invasive breast cancers, Nurses' Health Study (1976 to 1996)

From: Comparison of molecular phenotypes of ductal carcinoma in situand invasive breast cancer

Immunophenotype DCIS (n = 272) All invasive (n = 2249) Infiltrating ductal, NOS only (n = 1550) p valuea p valueb
  n (%) n (%) N (%)   
Luminal A 170 (62.5) 1650 (73.4) 1053 (67.9) 0.0002 0.08
Luminal B 36 (13.2) 116 (5.2) 90 (5.8) <0.0001 <0.0001
HER2+ 37 (13.6) 128 (5.7) 107 (6.9) <0.0001 <0.0001
Basal-like 21 (7.7) 245 (10.9) 223 (14.4) 0.15 0.005
Unclassified 8 (2.9) 110 (4.9) 77 (5.0) 0.15 0.14
  1. a p value from Chi-Squared test comparing DCIS to all invasive tumours.b p value from Chi-Squared test comparing DCIS to infiltrating ductal tumours. DCIS, ductal carcinoma in situ.