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Table 3 Mean percentage mammographic density (MD) according to breast cancer susceptibility loci, Nurses' Health Study controls (1989–1998)

From: Breast cancer susceptibility loci and mammographic density

   Premenopausal (n = 217) Postmenopausal (n = 904)
   N Mean %MDa Mean %MDb N Mean %MDa Mean %MDc
rs2981582 G/G 73 37.4 37.9 332 24.4 24.2
  G/A 112 40.5 40.7 407 23.9 23.6
  A/A 28 41.7 38.4 131 23.7 25.3
p value d    0.27 0.62   0.34 0.82
rs12443621 A/A 51 36.0 36.2 236 22.9 23.4
  A/G 104 38.9 39.1 442 24.5 24.2
  G/G 54 43.7 42.5 202 23.5 23.8
p value d    0.05 0.06   0.70 0.72
rs13281615 A/A 70 39.7 38.2 290 25.2 25.0
  A/G 94 36.0 38.2 445 23.7 23.9
  G/G 47 45.8 43.1 144 22.9 22.8
p value d    0.45 0.52   0.36 0.32
rs3817198 A/A 80 33.9 33.5 396 24.2 24.0
  A/G 106 42.6 42.3 368 24.4 24.6
  G/G 20 39.5 41.0 93 22.7 22.8
p value d    0.04 0.01   0.39 0.56
rs889312 T/T 107 41.1 41.3 499 25.6 25.4
  T/G 89 38.5 38.2 321 21.5 22.1
  G/G 14 38.8 37.2 58 26.8 25.3
p value d    0.40 0.21   0.17 0.14
rs4666451 G/G 74 40.7 41.6 314 24.0 24.5
  A/G 96 40.6 39.5 418 24.2 23.8
  A/A 36 33.0 33.6 144 24.3 24.3
p value d    0.13 0.06   0.90 0.40
rs2107425 G/G 105 41.7 40.7 449 24.3 24.6
  G/A 87 36.8 37.2 337 23.4 23.3
  A/A 18 37.5 39.6 85 24.6 23.6
p value d    0.11 0.29   0.79 0.37
rs981782 A/A 64 37.7 37.5 258 25.5 24.6
  A/C 100 39.4 39.2 429 23.7 24.1
  C/C 47 42.3 42.5 175 23.2 23.4
p value d    0.39 0.27   0.08 0.22
rs8051542 G/G 63 41.0 40.5 234 23.2 23.4
  G/A 73 40.0 40.1 296 22.3 22.3
  A/A 32 37.9 37.8 137 27.6 27.3
p value d    0.58 0.65   0.36 0.43
rs30099 C/C 175 38.8 38.8 723 24.4 24.5
  C/T 34 40.5 39.9 151 22.6 22.4
  T/T 0    8 26.0 21.8
p value d    0.45 0.51   0.49 0.16
rs3803662 G/G 107 37.0 36.9 458 23.9 24.1
  G/A 77 43.9 42.7 344 24.0 23.4
  A/A 20 32.7 36.1 69 26.5 28.0
p value d    0.55 0.34   0.64 0.50
  1. aAge adjusted.
  2. bMultivariate adjusted for the following: age (continuous), body mass index (BMI) (continuous), alcohol consumption (none, <5 g/day, 5 to 14.9 g/day, 15+ g/day), age at first birth/parity (nulliparous, age at first birth <25, age at first birth 25 to 29, age at first birth >30), history of benign breast disease (yes/no), family history of breast cancer (yes/no).
  3. cMultivariate adjusted for the following: age, BMI, alcohol consumption, age at first birth/parity, history of benign breast disease, family history of breast cancer, postmenopausal hormone use (never user, current user, past user).
  4. dp value based on genotype coded as ordinal variable regressed on square root transformed MD.