Pathway analysis of the Ox-E/ER gene signature. (a) Top scoring gene network represented in the Ox-E/ER gene signature. Ox-E/ER genes upregulated by oxidative stress are colored in red, and oxidative stress downregulated genes are colored in blue. Intensity of color reflects the magnitude of the average fold changes across the three oxidants as listed below the gene. Uncolored nodes are added by the Ingenuity Pathway Systems software, and are not present in the Ox-E/ER signature. Solid lines signify direct gene-gene interactions, whereas broken lines represent indirect relationships that may require secondary effectors not depicted in the network. All connections are supported by at least one published report or from canonical information stored in the Ingenuity Pathway Knowledge Base. (b) Number 2 scoring network represented in the Ox-E/ER gene signature. (c) Third top scoring network represented in the Ox-E/ER gene signature. ER, estrogen receptor; Ox-E/ER, oxidant-sensitive estrogen/ER gene signature.