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Table 1 Family characteristics

From: Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer

  Total (n = 187) Malay (n = 44) Chinese (n = 118) Indian (n = 22) Others (n = 3)
  No. (%) No. (%) No. (%) No. (%) No. (%)
Age of onset of breast cancer in index case (years)
20 to 29 14 (7) 3 (7) 10 (8) 1 (5) 0 (0)
30 to 39 64 (34) 21 (48) 36 (31) 6 (27) 1 (33)
40 to 49 49 (26) 8 (18) 35 (30) 5 (23) 1 (33)
≥ 50 60 (32) 12 (27) 37 (31) 10 (45) 1 (33)
Personal cancer history of breast, or breast and ovarian cancer
Breast only 182 (97) 43 (98) 117 (99) 19 (86) 3 (100)
Both breast and/or ovarian 5 (3) 1 (2) 1 (1) 3 (14) 0 (0)
Bilateral breast cancer 25 (13) 6 (14) 15 (13) 4 (18) 0 (0)
Family history of breast and ovarian cancer in pedigree
1 case (no family history) a73 (39) 24 (54) 40 (34) 8 (36) 1 (33)
2 cases 76 (41) 13 (30) 54 (46) 9 (41) 1 (33)
3 cases 24 (13) 4 (9) 17 (14) 2 (9) 0 (0)
≥ 4 cases 14 (7) 3 (7) 7 (6) 3 (14) 1 (33)
  1. A total of 187 breast cancer patients were analysed for mutations in BRCA1 and BRCA2 by DNA sequencing and multiple ligation dependent probe amplification (MLPA) analysis. Table 1 shows the distribution of patients according to their self-declared ethnicity, personal history of breast and ovarian cancer, and family history of breast and ovarian cancer in first- and second-degree relatives. aNotably, the 73 individuals with no family history of breast and ovarian cancer were included in the study because they had either early age of onset of breast cancer (≤ 40 years of age: 45 individuals; 41 to 55 years of age: nine individuals), bilateral breast cancer (16 individuals), both breast and ovarian cancer (one individual) or family history of prostate cancer in the third degree (three individuals).