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Table 2 Association of ISG15 immunoreactivity with clinical and pathological characteristics assessed in clinical routine examination of the validation set

From: The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer

Characteristic   Low ISG15(Score 0 to 3) High ISG15(Score 4 to 12) Total n (%) p-value
Total   333 (51.5) 313 (48.5) 646 (100) n/a
Age ( t -test) Mean (± SD) 57.3(± 12.2) 59.2 (± 12.4) 58.2 (± 12.3) 0.053
  Total 333 313 646  
Age < 50 91 (52.3) 83 (47.7) 174 (100) 0.05
  50–59 108 (59.3) 74 (40.7) 182 (100)  
  60–69 80 (45.7) 95 (54.3) 175 (100)  
  ≥ 70 54 (47.0) 61 (53.0) 115 (100)  
  total 333 (51.5) 313 (48.5) 646 (100)  
pT a pT1 185 (56.9) 140 (43.1) 325 (100) 0.006
  PT2 to 4 139 (45.9) 164 (54.1) 303 (100)  
  Total 324 (51.6) 304 (48.4) 628 (100)  
pN a pN0 193 (52.9) 172 (47.1) 365 (100) 0.504
  pN1 134 (50.2) 133 (49.8) 267 (100)  
  Total 327 (51.7) 305 (48.3) 632 (100)  
Grading 1 or 2 240 (55.0) 196 (45.0) 436 (100) 0.007
  3 90 (43.7) 116 (56.3) 206 (100)  
  Total 330 (51.4) 312 (48.6) 642 (100)  
Hormone receptor Status Negative 54 (43.2) 71 (56.8) 125 (100) 0.177
  Positive 234 (50.0) 234 (50.0) 468 (100)  
  Total 288 (48.6) 305 (51.4) 593 (100)  
  1. aAccording to Sobin LH, Wittekind CH: UICC: TNM Classification of Malignant Tumours. 6th edition, New York: Wiley; 2002 [36]. SD, Standard deviation; n/a, not available; pT, Pathological assessment of the primary tumour; pN, Pathological assessment of the regional lymph nodes.