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Table 1 Biological roles of insulin-like growth factor binding protein 5 (IGFBP-5) in different types of cancer

From: Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer

Cancer type Source of tissue or cell line Application of the study or study design Observed functional effects of IGFBP-5 Ref.
Breast T47D Intracellular trafficking Nuclear localization of IGFBP-5 [31]
  Hs578T Analysis of mitogenic effect of IGFBP-5 Protective effect against ceramide-induced apoptosis [104]
  Hs578T Cell attachment applications Cell attachment increased by exogenously added IGFBP-5 [110]
  MDA-MB-231 Cellular localization and apoptotic role of IGFBP-5 IGFBP-5 localizes in the nucleus and produces apoptosis [107]
  MDA-MB-231 Role of IGFBP-5 in the apoptotic pathway IGFBP-5 induces and activates caspase 8 and caspase 9 [108]
Neuroblastoma B104 Characterization of IGFBP-5 proteases A specific serine-metalloprotease for IGFBP-5 [122]
  LAN-5, N1E-115 Analysis of IGFBP-5 promoter sites c-Myb and B-Myb enhance IGFBP-5 transcription [45]
  LAN-5, SY5Y(N) Micro and small interfering RNAs directed to IGFBP-5 mRNA Growth inhibition and more prone to apoptosis [123]
  Various types of neuroblastoma cells Retinoic acid-induced differentiation Increased expression of IGFBP-5 [47, 124]
  LAN-5, SY5Y(N) Silencing IGFBP-5 Mitochondrial apoptosis [125]
Prostate CWR22, CaP xenograft Castration and androgen stimulation Androgen receptor upregulates IGFBP-5 [126]
  Mouse androgen-dependent Shionogi tumor model Castration-induction Upregulation of IGFBP-5 [97]
  LNCaP PC-3 Hormone treatment 1α,25(OH)2D3 treatment No significant effect on IGFBP-5 mRNA level [127]
    IGFBP-5 is primary target gene of the 1 α,25(OH)2D3 [128]
  Bone marrow stromal cells Androgen suppression treatment Increasing IGFBP-5 mRNA expression facilitates prostate cancer progression [129]
Osteosarcoma Osteosarcoma U2 cell line, untrans-formed normal human bone cells Proteolytic degradation of IGFBP-4 and IGFBP-5 Proteolytic activity of IGFBP-5 can modulate IGF action in bone [130]
  Rat osteosarcoma cells Relationship between growth hormone receptor and IGFBP-5 IGFBP-5 increases growth hormone receptor mRNA and growth hormone binding and potentiates mitogenesis [131]
  OS/50-K8 mouse osteosarcoma cells Biological activity of IGFBP-5 IGFBP-5 reduces proliferation and regulates differentiation [132]
  U2 human osteosarcoma cells Examination of IGFBP-5 proteases ADAM-9 cleaved IGFBP-5 specifically and is v [133]
  Bone cells Silencing of IGFBP-5 Knockdown of IGFBP-5 induced DNA synthesis and reduced differentiation [134]
  U2 human osteosarcoma cells Detection of IGFBP-5 interacting proteins A novel IGFBP-5 interacting protein (IGFBP5-IP) [135]
  LSaOS human osteosarcoma cell line IGFBP-5 regulations in bone Four-and-a-half LIM protein 2 and ADAM-9 are major modulators of IGFBP-5 actions [136]
Ovarian Human ovarian carcinoma lines IGFBP levels Expression of IGFBP-5 appears as a rather rare event [137]
Ovarian Various types of ovarian cancers Examine IGFBP-2 and IGFBP-5 levels Overexpression of IGFBP-5 in high-grade ovarian carcinoma [138]
  Ovarian cancer patients Evaluate predictive value of IGFBPs in aromatase inhibitor letrozole IGFBP-5 is a predictive marker for endocrine therapy [139]
Cervical HPV(-) C33A, HPV(+) CaSki cells Retinoic acid treatment IGFBP-5 overexpression determines retinoic acid effects in human papilloma virus(-) cells [48]
  Squamous cell carcinomas Cervical carcinogenesis Downregulation of IGFBP-5 [140]
Colon LoVo cells NS398 treatment IGFBP-5 might be a target of NS398 [141]
  Colon epithelial cells Leptin treatment Downregulation of IGFBP-5 by leptin treatment [142]
Renal Oncocytomas, clear cell and papillary renal cell carcinoma Changes of IGF/IGFBPs Downregulation of IGFBP-5 in papillary renal cell carcinoma and oncocytomas [143]
  Clear cell renal cell carcinoma Analysis of IGF-axis components Downregulation of IGFBP-5 [144]
Lung Lun squamous cell carcinomas, and normal bronchial epithelial tissues Identification of differentially expressed genes Overexpression of IGFBP-5 [145]
Gastric A panel of human gastric cancer cell lines, and normal and tumor tissues Detect IGFs and IGFBP levels One-half of the tumor cells express IGFBP-5 [146]
Thyroid Various types of thyroid tissues IGFBP-5 levels Overexpression of IGFBP-5 in papillary carcinoma [98]
Pancreas Pancreatic ductal adenocarcinoma Differential expression of genes Overexpression of IGFBP-5 [147]
  1. 1α,25(OH) 2D3 = 1α,25-dihydroxyvitamin D3; IGF = insulin-like growth factor; IGFBP = insulin-like growth factor binding protein.
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