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Table 4 Mean body mass index and adult weight change by IRS2 SNPs

From: Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II

IRS2 SNP

 

Cases

Controls

  

BMI

Adult weight changea

BMI

Adult weight changea

  

Mean

(SE)

Mean

(SE)

Mean

(SE)

Mean

(SE)

rs9515118

G/G

24.98

(0.23)

26.92

(1.33)

25.48

(0.22)

26.48

(1.29)

 

G/C

25.66

(0.32)

30.94

(1.85)

25.57

(0.32)

27.6

(1.83)

 

C/C

25.23

(0.85)

25.36

(4.90)

25.57

(0.98)

33.07

(5.64)

 

P trend

0.16

 

0.29

 

0.82

 

0.31

 

rs4773082

T/T

25.41

(0.37)

26.56

(2.11)

25.12

(0.32)

25.87

(1.81)

 

T/C

25.2

(0.25)

27.81

(1.44)

25.64

(0.27)

27.43

(1.51)

 

C/C

25.17

(0.37)

29.77

(2.07)

25.8

(0.38)

28.07

(2.16)

 

P trend

0.64

 

0.28

 

0.15

 

0.42

 

rs2289046

A/A

25.49

(0.28)

30.71

(1.55)

25.54

(0.29)

27.5

(1.65)

 

A/G

24.97

(0.29)

26.09

(1.66)

25.52

(0.27)

27.06

(1.52)

 

G/G

25.18

(0.82)

22.46

(4.60)

24.98

(0.60)

22.68

(3.39)

 

P trend

0.28

 

0.016

 

0.53

 

0.31

 

rs754204

C/C

24.99

(0.37)

24.42

(2.10)

25.13

(0.32)

25.45

(1.84)

 

C/T

25.2

(0.25)

27.65

(1.43)

25.57

(0.26)

27.39

(1.46)

 

T/T

25.55

(0.36)

31.77

(2.04)

25.9

(0.38)

28.38

(2.18)

 

P trend

0.28

 

0.012

 

0.12

 

0.29

 

rs7987237

C/C

25.17

(0.21)

28.3

(1.20)

25.58

(0.21)

27.24

(1.17)

 

C/T

25.44

(0.37)

26.95

(2.09)

25.24

(0.38)

25.89

(2.13)

 

T/T

25.1

(1.18)

25.73

(6.66)

25.51

(1.44)

34.45

(8.16)

 

P trend

0.62

 

0.51

 

0.48

 

0.94

 

rs12584136

C/C

25.16

(0.19)

27.36

(1.08)

25.54

(0.19)

27.02

(1.07)

 

C/A

26.36

(0.63)

35.86

(3.56)

24.97

(0.61)

25.58

(3.49)

 

A/A

25.52

(2.28)

34.05

(12.85)

30.06

(2.60)

57.32

(14.83)

 

P trend

0.1

 

0.026

 

0.95

 

0.61

 

rs9559648

C/C

25.34

(0.28)

27.65

(1.59)

25.38

(0.26)

26.05

(1.48)

 

C/T

25.26

(0.26)

28.86

(1.49)

25.61

(0.28)

27.84

(1.59)

 

T/T

24.61

(0.57)

25.55

(3.20)

25.64

(0.53)

27.16

(3.02)

 

P trend

0.34

 

0.87

 

0.54

 

0.53

 

rs9559654

G/G

25.05

(0.26)

26.14

(1.49)

25.68

(0.26)

27.39

(1.46)

 

G/A

25.2

(0.29)

28.47

(1.64)

25.19

(0.29)

26.63

(1.64)

 

A/A

25.74

(0.56)

31.38

(3.15)

25.64

(0.59)

25.8

(3.36)

 

P trend

0.3

 

0.1

 

0.47

 

0.62

 

rs7997595

C/C

25.38

(0.22)

29.46

(1.25)

25.39

(0.21)

26.26

(1.21)

 

C/G

24.83

(0.36)

25.5

(2.05)

25.83

(0.35)

28.77

(2.00)

 

G/G

25.58

(1.04)

25.76

(5.94)

25.91

(1.58)

33.47

(9.08)

 

P trend

0.38

 

0.11

 

0.27

 

0.2

 

rs7981705

C/C

25.2

(0.22)

27.1

(1.24)

25.3

(0.21)

26.3

(1.19)

 

C/T

25.2

(0.33)

29.07

(1.88)

25.84

(0.35)

28.28

(2.03)

 

T/T

26.24

(1.10)

34.9

(6.22)

27.62

(1.04)

32.52

(5.90)

 

P trend

0.63

 

0.18

 

0.026

 

0.22

 

rs4773092

G/G

25.25

(0.38)

8.65

(2.14)

25.66

(0.35)

26.36

(2.01)

 

G/A

25.22

(0.25)

28.19

(1.42)

25.3

(0.26)

26.78

(1.52)

 

A/A

25.28

(0.40)

27.03

(2.26)

25.85

(0.42)

28.5

(2.41)

 

P trend

0.96

 

0.61

 

0.86

 

0.52

 
  1. All results are age-adjusted. aAdult weight change is measured in pounds (lbs) from the weight at age 18 years to the weight in 1992. BMI, body mass index; IRS2, insulin receptor substrate 2 gene; SE, standard error.
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Breast Cancer Research

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