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Figure 1 | Breast Cancer Research

Figure 1

From: The aromatase inhibitor letrozole and inhibitors of insulin-like growth factor I receptor synergistically induce apoptosis in in vitro models of estrogen-dependent breast cancer

Figure 1

Combination of AEW541 and letrozole is synergistic in inhibiting androstenedione-dependent proliferation. Steroid-deprived MCF7/Aro (upper panels) and T47D/Aro (lower panels) cells were treated with androstenedione (Δ4A) in the presence of increasing concentrations of letrozole and/or AEW541 for 6 days. Percentage inhibition of proliferation was determined (as described in the text), and combination index (CI) values of the two agents plotted, according to a (a,c) nonexclusive Monte Carlo extrapolation. (b,d) Similarly, a conservative isobologram was plotted. ED, effective dose; s.d., standard deviation.

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Breast Cancer Research

ISSN: 1465-542X

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