Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort

Table 1 SEARCH participant survival characteristics

	Set 1		Sets 1 and 2
	n = 2,270		n = 4,470
Total time at risk, years	1,3851.47		2,5049.24
Median follow-up, years^a	7.75	(0.56–10)^b	7.45	(0.48–10)^b
Median time at risk, years	6.47	(0.10–9.64)^b	5.70	(0.03–9.77)^b
Median time from diagnosis to study entry, years	0.73	(0.00–8.64)^b	1.16	(0.00–9.34)^b
Number of deaths	359		637
Annual mortality rate	0.026		0.025
5-year survival rate	0.88	(0.86–0.89)^c	0.88	(0.87–0.89)^c
Median age at diagnosis, years	50.2	(25–69)^b	51.0	(23–69)^b
Age at diagnosis, years
<40	212	9.30%	394	8.81%
40–49	753	33.20%	1,331	29.78%
50–59	997	43.90%	1,802	40.31%
60+	308	13.60%	943	21.10%
Histopathological grade
Well differentiated	434	19.11%	871	19.49%
Moderately differentiated	787	34.67%	1,687	37.74%
Poorly differentiated	504	22.20%	1,019	22.80%
Unknown	545	24.00%	893	19.98%
Morphological type
Ductal	1,674	73.74%	3,316	74.18%
Lobular	351	15.46%	659	14.74%
Other	222	9.78%	455	10.17%
Unknown	23	1.01%	40	0.89%
Clinical stage
1	1,112	48.99%	2,190	48.99%
2	986	43.33%	1,981	44.32%
3 or 4	172	7.58%	194	4.34%
Missing	0	0%	105	2.35%

^aFollow-up censored at 10 years. ^bRange of variable. ^c95% confidence interval. SEARCH, Studies of Epidemiology and Risk factors in Cancer Heredity.

ISSN: 1465-542X