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Table 4 Comparison of primary tumor gene methylation status relative to ER status

From: Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors

Gene

ER negative (n = 65)

ER positive (n = 65)

P valuea

 

n

%

n

%

 

RASSF1A

36

55%

60

92%

<0.0001

CCND2

26

40%

45

69%

0.0008

GSTP1

4

6%

19

29%

0.0006

TWIST

17

26%

32

49%

0.0066

APC

20

31%

31

48%

0.048

NES1

13

20%

22

34%

NS

RARβ2

18

28%

17

26%

NS

CDH1

53

82%

54

83%

NS

  1. aχ2 test or Fisher's exact test was used appropriately. ER, estrogen receptor; NS, not significant.
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Breast Cancer Research

ISSN: 1465-542X

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