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Table 4 Comparison of primary tumor gene methylation status relative to ER status

From: Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors

Gene ER negative (n = 65) ER positive (n = 65) P valuea
  n % n %  
RASSF1A 36 55% 60 92% <0.0001
CCND2 26 40% 45 69% 0.0008
GSTP1 4 6% 19 29% 0.0006
TWIST 17 26% 32 49% 0.0066
APC 20 31% 31 48% 0.048
NES1 13 20% 22 34% NS
RARβ2 18 28% 17 26% NS
CDH1 53 82% 54 83% NS
  1. aχ2 test or Fisher's exact test was used appropriately. ER, estrogen receptor; NS, not significant.