Table 3 Effect of a subsequent pregnancy on outcome in breast cancer survivors
From: Cancer and fertility preservation: fertility preservation in breast cancer patients
Reference | Year | Patients (n) | Controls (n) | Relative risk (95% confidence interval) of recurrence or death/% recurrence | Outcome |
|---|---|---|---|---|---|
Ariel and Kempner [62] | 1989 | 47 | Â | 30% recurrence | No adverse effect on survival |
Sutton and colleagues [63] | 1990 | 23 | 204 | 28% recurrence, 3 deaths | No adverse effect on survival |
Sankila and colleagues [64] | 1994 | 91 | 471 | 0.20 (0.10 to 0.50) | No adverse effect on survival |
von Schoultz and colleagues [65] | 1995 | 50 | 2,119 | 0.48 (0.18 to 1.29) | No adverse effect on survival |
Malamos and colleagues [66] | 1996 | 21 | 222 | 14.3% recurrence | No adverse effect on survival |
Kroman and colleagues [67] | 1997 | 173 | 5,514 | 0.55 (0.28 to 1.06) | Decreased risk in pregnant women |
Velentgas and colleagues [68] | 1999 | 3 | 265 | 0.80 (0.30 to 2.30) | No adverse effect on survival |
Gelber and colleagues [69] | 2001 | 94 | 94 | 0.44 (0.21 to 0.46) | Decreased risk in pregnant women |
Müller and colleagues [70] | 2003 | 438 | 2,775 | 0.54 (0.41 to 0.71) | Decreased risk in pregnant women |
Blakely and colleagues [71] | 2004 | 47 | 323 | 0.70 (0.25 to 1.95) | No adverse effect on survival |
Ives and colleagues [72] | 2007 | 123 | 2,416 | 0.59 (0.37 to 0.95) | Decreased risk in pregnant women |
Total | Â | 1,110 | 14,164 | Â | Â |