From: Cancer and fertility preservation: fertility preservation in breast cancer patients
 |  |  |  |  |  | Rate of amenorrhea | |
---|---|---|---|---|---|---|---|
Reference | Year | Patients (n) | Chemotherapy regimen | Duration of treatment (months) | Follow-up to definite amenorrhea (months) | Percentage | Age (years) |
Goldhirsch and colleagues [4] | 1990 | 541 | CMF | 1 | 9 | 14/34 | <40/>40 |
 |  | 387 |  | 6 |  | 33/81 | <40/>40 |
Bines and colleagues [5] | 1996 | 3,628 | CMF | 3 to 24 | 12 | 40/76 | <40/>40 |
Levine and colleagues [6] | 1998 | 359 | CMF | 6 | NA | 42.6 | Â |
 |  | 132 | FEC | 6 |  |  |  |
Goodwin and colleagues [7] | 1999 | 83 | CMF | 6 | 12 | 55.6 | Â |
 |  | 25 | FEC | 6 |  | 64.6 |  |
Nabholtz and colleagues [8] | 2002 | 745 | ACD | 6 | 33 | 51.4 | Â |
 |  | 746 | FAC | 6 |  |  |  |
Fornier and colleagues [9] | 2005 | 84 | AC-T/D | 6 | 12 | 13 | Â |
 |  | 82 | AC-T/D + tamoxifen |  |  | 17 |  |
Martin and colleagues [10] | 2005 | 420 | ACD | 6 | NA | 61.7 | Â |
 |  | 403 | FAC |  |  | 52.4 |  |
Venturini and colleagues [11] | 2005 | 503 | FEC | 4 | 120 | 64 | Â |
Petrek and colleagues [12] | 2006 | 120 | AC | 4 | 36 | 53 | Â |
 |  | 168 | ACT | 6 |  | 42 |  |
 |  | 83 | CMF | 8 |  | 82 |  |
 |  | 38 | FAC | 6 |  | NA |  |
 |  | 34 | FACT | 6 |  | NA |  |
 |  | 19 | ACD | 6 |  | 45 |  |
Tham and colleagues [13] | 2007 | 75 | AC | 4 | 12 | 44/81 | <40/>40 |
 |  | 116 | AC + T/D | 4 + 3 |  | 61/85 | <40/>40 |
Total | Â | 8,681 | Â | Â | Â | Â | Â |