A total of 1,145 patients were recruited from March 2003 to July 2007. One patient was randomised in error and therefore excluded. Eight hundred and fourteen out of 1,139 (71%) had significant dose inhomogeneity with standard 2D RT, and were randomised to IMRT or control; 325/1,139 (29%) had acceptable dose homogeneity, and were treated with standard 2D RT. The mean improvement in volumes >107% for IMRT plans was 34 cm3 (P < 0.0001, 95% CI = 26 to 42 cm3). The mean improvement in volumes <95% for IMRT plans was 48 cm3 (P = 0.0001, 95% CI = 34 to 62 cm3).
The mean difference in breast volume between randomised and nonrandomised patients was 596 cm3 (P < 0.0001, 95% CI = 530 to 662 cm3). We aim to report the acute and interim late side effects in spring 2008, if the data are released by the Independent Data Monitoring Committee.