Background
Advances in the understanding of the molecular basis of breast cancer has necessitated a definition of more sensitive and specific indicators of prognosis that are central to the underlying cancer biology and that reflect the complicated and heterogeneous nature of the disease. The present study investigates the pattern of expression of the steroid receptor coregulators NCOA1/SRC1, NCOA3/RAC3, NCOR2/SMRT, and CBP/p300 in breast cancer. The aims were to identify whether their expression was related to patient outcome, their relationships to known prognostic factors and to provide a basis for further research to investigate the mechanistic significance of such associations.