Figure 1

Modulation of tumor multiplicity during treatment with tamoxifen and celecoxib alone and in combination. Efficacies of (a, b) tamoxifen or celecoxib alone and (c, d) tamoxifen, celecoxib or combination treatment to prevent the development of mammary carcinomas in (a, c) intact rats and (b, d) ovariectomized rats. Tumor multiplicity curves labeled with the average number of mammary carcinomas per rat at the date of necropsy.