Table 3 Cox proportional hazards analysis for overall and disease-free survival

FISH

HER1

   Continuous 0.1

1.02

0.97–1.07

0.380

1.03

0.98–1.07

0.301

   Continuous 1.0

1.24

0.77–2.00

1.28

0.80–2.03

HER2

   Continuous 0.1

1.02

1.01–1.02

0.001

1.02

1.01–1.03

<0.001

   Continuous 1.0

1.16

1.06–1.26

1.18

1.08–1.29

   Dichotomous (≤1.5 vs. ≥1.6)

2.07

1.33–3.21

0.001

2.33

1.48–3.68

<0.001

HER3

   Continuous 0.1

1.07

0.99–1.15

1.09

1.01–1.18

0.031

   Continuous 1.0

1.88

0.88–4.01

0.102

2.35

1.08–5.11

HER4

   Continuous 0.1

0.90

0.75–1.09

0.289

0.92

0.76–1.12

0.395

   Continuous 1.0

0.36

0.06–2.36

0.43

0.06–3.03

IHC

HER1

1.66

0.96–2.86

0.070

1.55

0.87–2.77

0.139

HER2

1.42

0.90–2.25

0.131

1.58

0.99–2.54

0.057

HER3

0.84

0.51–1.37

0.484

0.93

0.55–1.56

0.778

HER4

1.48

0.97–2.26

0.070

1.51

0.97–2.33

0.066

HER2 divided

1.72

1.07–2.75

0.024

1.89

1.16–3.08

0.010

Ki-67

1.49

0.87–2.55

0.145

1.44

0.83–2.49

0.197

ER

0.58

0.37–0.91

0.018

0.59

0.37–0.96

0.031

PR

0.48

0.27–0.74

0.002

0.42

0.24–0.71

0.001

Histology

pT

1.62

1.35–1.93

<0.001

1.72

1.43–2.08

<0.001

pN

1.98

1.67–2.35

<0.001

2.18

1.81–2.62

<0.001

Grading

2.10

1.54–2.87

<0.001

2.18

1.56–3.05

<0.001