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Table 2 Interaction between the polymorphisms: p53 codon 72 and BRCA2 -26 in sporadic breast cancer patients and normal controls

From: Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53codon 72 Arg>Pro polymorphism

Genotypic combination

Patients

Controls

  

p53 codon 72

BRCA2 -26

N = 243

N = 333

P a

OR (95% CI)b

Pro/Pro

G/G

38 (15.63%)

45 (13.51%)

-

1 (referent)

Pro/Pro

G/A

7 (2.88%)

46 (13.81%)

0.0002c

0.2 (0.1–0.4)

Pro/Pro

A/A

3 (1.23%)

6 (1.80%)

0.476

0.6 (0.1–2.5)

Pro/Arg

G/G

59 (24.27%)

78 (23.42%)

0.686

0.9 (0.5–1.5)

Pro/Arg

G/A

38 (15.64%)

68 (20.42%)

0.166

0.7 (0.4–1.2)

Pro/Arg

A/A

12 (4.94%)

14 (4.20%)

0.983

1.0 (0.4–2.4)

Arg/Arg

G/G

47 (19.34%)

34 (10.21%)

0.120

1.6 (0.9–3.0)

Arg/Arg

G/A

29 (11.93%)

38 (11.41%)

0.754

0.9 (0.5–1.7)

Arg/Arg

A/A

10 (4.11%)

4 (1.20%)

0.087

3.0 (0.9–10.2)

  1. a,b P values and corresponding age-adjusted ORs with 95% CIs for comparison of combination of genotype frequencies between breast cancer patients and controls by logistic regression. c P values continue to remain significant after applying Bonferroni correction of 9 (9 combinations tested in a case-control group) to correct for multiple comparisons. CI, confidence interval; OR, odds ratio.