Figure 6

HGFIN reporter gene activity in MDA-MB-231, ectopically expressed for p53. (a) MDA-MB-231 was co-transfected with pLuc and/or pME18S-SCX3 expression p53, mutant or vector alone. K562 transfected with pLuc served as control. The results are presented as mean ± SD, n = 5. (b) MDA-MB-231 was co-expressed with HGFIN-RM/2.0 or HGFIN-RM/2.0E and/or p53 expression vector, pME18S-SCX3. Controls were co-transfected with p53 mutants or vector alone. The results were normalized with β-galactosidase and are presented as mean ± SD, n = 6. *p < 0.05 vs vector/untransfected and mutant p53.