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Table 2 Methylation levels of 15 genes from pairs of normal and malignant breast tissues

From: Correlation between CpG methylation profiles and hormone receptor status in breast cancers

Gene Number of cases studied Methylation level (mean ± SD) (Positive rate*)
   Normal Cancer pvalue**
LINE1 90 68 ± 4 60 ± 9 < 0.001
RIL 90 10 ± 4 (4.5) 27 ± 22 (57) < 0.001
HIN-1 90 5 ± 3 (2.3) 20 ± 20 (49) < 0.001
RASFF1A 90 3 ± 3 (3.4) 19 ± 20 (58) < 0.001
CDH13 90 3 ± 2 (0) 14 ± 13 (44) < 0.001
RARβ2 90 2 ± 1 (0) 7 ± 12 (17) < 0.001
ARHI CpG I 32 30 ± 6 (0) 47 ± 16 (49) < 0.001
ARHI CpG II 32 38 ± 7 (2) 36 ± 10 (2) 0.250
RIZ1 37 2 ± 2 (0) 3 ± 4 (5) 0.111
E-cadherin 34 4 ± 3 (3) 4 ± 4 (9) 0.163
p16 33 2 ± 1 (0) 1 ± 1 (0) 0.044
hMLH1 33 2 ± 3 (6) 1 ± 1 (0) 0.864
14-3-3 σ 10 75 ± 21 60 ± 28 0.275
NKD2 47 2 ± 4 (2) 4 ± 7 (8.5) 0.308
PGRB 48 3 ± 2 (0) 2 ± 3 (0) 0.594
ERα 40 7 ± 4 (3) 5 ± 3 (5) < 0.001
  1. *Positive rate using the sample mean plus two times the SD of the pooled normal samples (and minimum 10% methylation) as a cut-off point.
  2. **p value computed using the Wilcoxon signed rank test for paired data. SD, standard deviation.