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Table 4 Median values and median percentage change from baseline for plasma concentrations of estrogens (mITT population)

From: Effects of steroidal and nonsteroidal aromatase inhibitors on markers of bone turnover in healthy postmenopausal women

Estrogen Exemestane (n= 20) Letrozole (n= 20) Anastrozole (n= 18) Placebo (n= 20)
E1
Baseline, median (min., max.) 31 (11, 72) 28 (13, 51) 29 (14, 61) 26 (9.9, 61)
Week 12, median (min., max.) 2.0 (1.8, 10) 1.8 (1.8, 20) 1.8 (1.8, 84) 31 (8.4, 58)
   % baseline, median (95% CI*) 7.8 (6.9, 9.3) 6.6 (5.5, 8.1) 7.6 (6.4, 11) 101 (89, 110)
Week 24, median (min., max.) 1.8 (1.8, 63) 1.8 (1.8, 33) 1.8 (1.8, 44) 26 (7.2, 56)
   % baseline, median (95% CI) 6.7 (5.3, 8.6) 6.6 (5.1, 8.1) 7.9 (7.1, 11) 94 (76, 108)
Week 36, median (min., max.) 23 (10, 62) 19 (10, 44) 25 (8.4, 158) 22 (13, 46)
   % baseline, median (95% CI) 72 (63, 86) 76 (61, 93) 70 (66, 121) 89 (72, 95)
E 2
Baseline, median (min., max.) 4.4 (1.1, 13) 4.2 (1.8, 8.6) 3.8 (1.9, 32) 3.9 (1.9, 8.8)
Week 12, median (min., max.) 0.70 (0.70, 2.5) 0.70 (0.70, 2.7) 0.70 (0.70, 104) 3.8 (1.6, 15)
   % baseline, median (95% CI) 18 (14, 22) 19 (14, 24) 20 (18, 31) 102 (87, 115)
Week 24, median (min., max.) 0.70 (0.70, 29) 0.70 (0.70, 7.3) 0.72 (0.70, 84) 4.4 (1.9, 12)
   % baseline, median (95% CI) 19 (13, 22) 18 (13, 24) 22 (19, 31) 128 (95, 139)
Week 36, median (min., max.) 4.5 (1.6, 36) 4.2 (1.9, 15) 4.2 (1.4, 136) 4.0 (1.6, 11)
   % baseline, median (95% CI) 103 (89, 134) 109 (81, 119) 106 (92, 130) 105 (90, 130)
E 1 S
Baseline, median (min., max.) 192 (58, 757) 193 (79, 1075) 202 (64, 896) 200 (62, 1156)
Week 12, median (min., max.) 13 (8.7, 246) 8.7 (6.0, 62) 15 (6.6, 3260) 209 (58, 876)
   % baseline, median (95% CI) 9.1 (6.1, 11) 4.5 (3.3, 6.0) 11 (6.7, 13) 110 (91, 146)
Week 24, median (min., max.) 16 (6.1, 839) 10 (6.0, 254) 18 (8.8, 1440) 195 (64, 802)
   % baseline, median (95% CI) 11 (7.2, 13) 4.7 (3.0, 7.2) 10 (8.6, 20) 105 (69, 123)
Week 36, median (min., max.) 223 (7.4, 2100) 222 (115, 932) 296 (58, 4890) 205 (68, 864)
   % baseline, median (95% CI) 114 (90, 152) 121 (105, 135) 131 (109, 147) 125 (91, 143)
  1. *95% CI, bias-corrected and adjusted 95% bootstrap CI for median.
  2. CI, confidence interval; E1, estrone; E1S, estrone sulfate; E2, estradiol; max; min; mITT, modified intent to treat.