Is breast cancer prognosis inherited?

Breast Cancer Research

Table 2 Survival model of the cause-specific mortality of women with primary breast cancer by prognosis in proband^a

	Deaths	Adjusted^b	Adjusted^c
		HR (95% CI)	HR (95% CI)
2,787 Mother-daughter pairs
Proband prognosis^d
Poor (tertile 1: <33%)	84	1.6 (1.1–2.3)	1.6 (1.1–2.3)
Medium (tertile 2: 33%–66%)	83	1.4 (1.0–2.0)	1.4 (1.0–2.0)
Good (tertile 3: >67%)	53	1.0 reference	1.0 reference
Test for trend		p = 0.007	p = 0.006
831 Sister pairs
Proband prognosis^d
Poor (tertile 1: <33%)	26	1.7 (0.9–3.2)	1.8 (1.0–3.4)
Medium (tertile 2: 33%–66%)	23	1.4 (0.7–2.6)	1.5 (0.8–2.9)
Good (tertile 3: >67%)	17	1.0 reference	1.0 reference
Test for trend		p = 0.08	p = 0.06
Combined (daughter and sister)
Proband prognosis^d
Poor (tertile 1: <33%)	110	1.6 (1.2–2.2)	1.6 (1.2–2.2)
Medium (tertile 2: 33%–66%)	106	1.4 (1.0–1.9)	1.4 (1.1–1.9)
Good (tertile 3: >67%)	70	1.0 reference	1.0 reference
Test for trend		p = 0.002	p = 0.002

^aCox proportional hazards model of the 5-year cause-specific mortality of 3,618 women with primary breast cancer by prognosis in proband (mother or older sister). ^bAdjusted for age and period of diagnosis of the daughter or younger sister. ^cAdjusted for age and period of diagnosis, parity, age at first birth, socioeconomic status, and area of residence of the daughter or younger sister. ^dProband's 5-year cause-specific prognosis as defined by separated Cox proportional hazards model adjusted for proband's age and period of diagnosis. CI, confidence interval; HR, hazard ratio.

ISSN: 1465-542X