Skip to main content

Table 1 Clinical and histopathological characteristics of cases included in the study

From: TP53mutation status and gene expression profiles are powerful prognostic markers of breast cancer

  All cases (n = 212) Microarray (n = 80)
Characteristics Number Percent Number Percent
Age (year)     
   <45 24 11.3 6 7.5
   45–55 37 17.5 12 15.0
   55–65 38 17.9 20 25.0
   65–75 50 23.6 21 26.3
   ≥75 63 29.7 21 26.3
Gender     
   Female 211 99.5 79 98.8
   Male 1 0.5 1 1.2
Type     
   Ductal 132 64.4 51 63.8
   Lobular 53 25.8 22 27.5
   Mucinous 8 3.9 3 3.8
   Medullary 4 2.0 0 0
   DCIS with microinvasion 1 0.5 1 1.3
   Tubulolobular 2 1.0 2 2.5
   Other 5 2.4 1a 1.3
   Unknown 7   0  
Tumor size     
   pT1 (≤2 cm) 71 34.6 20 26.0
   pT2 (>2 ≤5 cm) 112 54.6 44 57.1
   pT3 (>5 cm) 15 7.3 8 10.4
   pT4 (infiltrating growth) 7 3.4 5 6.5
   Unknown 7   3  
Node status     
   pN0 (negative) 95 44.8 33 41.3
   pN1 (1–3 positive) 48 22.6 23 28.8
   pN2–N3 (≥4 positive) 33 15.6 12 15.0
   pNX (Nodes not removed) 36 17.0 12 15.0
Grade     
   1 19 9.0 6 7.5
   2 141 66.5 53 66.3
   3 48 22.6 21 26.3
   Unknown 4   0  
Estrogen receptor     
   Positive 109 57.7 45 62.5
   Negative 80 42.3 27 37.5
   Unknown 23   8  
Progesteron receptor     
   Positive 130 62.8 51 67.1
   Negative 77 37.2 25 32.9
   Unknown 5   4  
TP53 mutation     
   Mutation 48 23.6 20 25.0
   Wild type 155 76.4 60 75.0
   Unknown 9   0  
Gene expression group     
   Luminal A    23 28.8
   Highly proliferating luminal    15 18.8
   Normal-like    20 25.0
   Basal-like    12 15.0
   ERBB2+    10 12.5
Adjuvant therapy     
   Radiation therapy     
Yes 60 31.1 25 32.9
No 133 68.9 51 67.1
Unknown 19   4  
   Chemotherapyb     
Yes 27 12.9 11 14.1
No 182 87.1 67 85.9
Unknown 3   2  
   Hormonal treatmentc     
Yes 53 25.1 25 31.6
No 158 74.9 54 68.4
Unknown 1    
Recurrence (distant metastisis)     
   Positive 72 34.1 34 42.5
   Negative 139 65.9 46 57.5
   Unknown 1   0  
Status     
   Alive 75 37.5 25 32.5
   Dead of disease 63 31.5 30 39.0
   Dead of other cause 60 30.0 20 26.0
   Emmigrated 2 1.0 2 2.6
   Unknown 12   3  
  1. aRare type with a metaplastic core and spindle cell component. bCMF × 9 (cyclophosphamide, methotrexate, 5-fluorouracil). cTamoxifen; 2 years. DCIS, ductal carcinoma in situ.