Clinical, histopathological and molecular characteristics of subgroups. Dendrogram from hierarchical clustering with distribution of clinical, histopathological and molecular markers between the five gene expression groups (highly proliferating luminals, luminal A, normal-like, basal-like, and ERBB2+). The color coding is as follows: red, description to the left; gray, unknown; yellow, all other. P values from cross-tabulation and Pearson X
2-test are shown to the right of the panel. Relative expression of mRNA is shown for TP53 (Clone-ID: IMAGE:24415 and IMAGE:236338) and estrogen receptor (ER) (IMAGE:725321). The fraction of malignant cells in tumor tissue and histological type are shown in the lower panel: DCIS, ductal carcinoma in situ with microinvasion IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; MPC, metaplastic carcinoma; MUC, mucinous carcinoma; TLC, tubulolobular carcinoma. ILC* is the 'typical lobular' type previously described . IHC, immunohistochemistry; LOH, loss of heterozygosity.