Figure 4
From: TP53mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Clinical, histopathological and molecular characteristics of subgroups. Dendrogram from hierarchical clustering with distribution of clinical, histopathological and molecular markers between the five gene expression groups (highly proliferating luminals, luminal A, normal-like, basal-like, and ERBB2+). The color coding is as follows: red, description to the left; gray, unknown; yellow, all other. P values from cross-tabulation and Pearson X 2-test are shown to the right of the panel. Relative expression of mRNA is shown for TP53 (Clone-ID: IMAGE:24415 and IMAGE:236338) and estrogen receptor (ER) (IMAGE:725321). The fraction of malignant cells in tumor tissue and histological type are shown in the lower panel: DCIS, ductal carcinoma in situ with microinvasion IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; MPC, metaplastic carcinoma; MUC, mucinous carcinoma; TLC, tubulolobular carcinoma. ILC* is the 'typical lobular' type previously described [36]. IHC, immunohistochemistry; LOH, loss of heterozygosity.