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Table 2 Frequencies of contralateral breast cancer patients CBC carrying apathogenic DNA-damage repair pathway mutation

From: Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study

Parameter Breast cancer < 50 yearsa (percentage) All CBC patients (n = 247) Previous RT (n = 169) No RT (n = 78) Carriers versus non-carriers
   n Percentage n Percentage n Percentage OR for CBC after RT 95% CI p
DDRP mutated ~10 51 21 41 24.3 10 12.8 2.18 1.03–4.62 0.043
CHEK2 1–2 15 6.1 13 7.7 2 2.6 3.17 0.69–14.39  
BRCA1 ~4–5 27 11.3 20 11.8 7 9 1.36 0.55–3.37  
BRCA2 ~0.5–1 5 2 4 2.4 1 1.3 1.87 0.21–16.98  
ATM truncating ~1–2 4 1.6 4 2.4 0 0 - -  
       1b 1.3 1.87 0.21–16.98  
  1. Results for all contralateral breast cancer (CBC) patients, and patients stratified by previous radiation exposure, are presented. Odds ratio (OR) and 95% confidence interval (CI) are given for mutation carriers versus non-carriers to develop radiation-associated breast cancer. DDRP, DNA-damage repair pathway; RT, radiation treatment. aPublished results; bHypothetical assumption of one case.
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