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Table 1 Clinical and biological characteristics of patients with MBCs and BLCs

From: Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity

Case no. Age (years) TNM stage Histoprognostic grade TP53 status  
BLC      
1 69 T2N0 3 ex7 G→A/p. Arg 248 Gln
2 66 T1N0 2 ex5 G→T/p. Cys 176 Phe
3 60 T2N0 2 ex8 G→A/p. Asp 281 Asn
4 64 T2N0 2 int6 Splice
5 51 T2N1a 3 wt -
6 62 T1N1a 2 wt -
7 70 T1N0 3 ex7 G→A/p. Gly 245 Ser
8 37 T1N0 2 ex6 C→T/p. Arg 213 STOP
9 62 T2N0 2 ex6 T→G/p. Ser 215 Arg
10 60 T2N1b 3 ex8 C→T/p. Arg 282 Trp
11 52 T2N1 3 ex6 C→T/p. Arg 213 STOP
12 50 T3N1 3 ex5 G→A/p. Arg 175 His
13 79 T2N0 3 ex5 C→T/p. Ala 159 Val
14 48 T2N0 3 ex10 Del codon 333
15 42 T1N0 3 ex6 Del codon 196
16 52 T2N1b 2 wt -
17 82 T2N0 3 wt -
18 46 T2N1a 3 nd -
19 51 T2N0 3 nd -
20 81 T2N0 3 ex7 A→G/p. Tyr 236 Cys
21 n.d. T2N0 3 ex6 T→C/p. Ile 195 Thr
22 40 T1cN0 3 ex6 T→G/p. Leu 194 Arg
23 69 T2N0 3 ex5 G→A/p. Arg 175 His
24 69 T2N0 3 ex5 C→A/p. Tyr 126 STOP
25 55 T2N0 3 ex6 C→T/p. Arg 213 STOP
26 77 T2N1 3 ex7 A→C/p. Thr 253 Pro
MBC      
1 46 T1cN1 3 ex7 Del codon 241
2 34 nd 3 ex7 Del codon 252
3 46 T2N0 3 ex5 G→A/p. Arg 175 His
4 72 T1cN0 3 ex8 G→A/p. Arg 280 Lys
5 39 T3N1 3 wt -
6 53 T2N0 3 nd -
7 49 T1cN0 3 nd -
8 49 T1cN0 3 nd -
9 33 T2N0 3 nd -
10 63 T2N0 3 nd -
11 66 T2N0 3 nd -
12 50 T1cN1a 3 nd -
13 57 T1cN0 3 ex7 G→A/p. Arg 248 Gln
14 68 T2N0 3 ex6 C→T/p. Arg 213 STOP
15 61 T2N0 3 ex6 A→G/p. Tyr 220 Cys
16 56 T2N0 3 wt -
17 58 T2N0 3 ex8 G→A/p. Glu 286 Lys
18 57 T2N0 3 ex8 G→A/p. Cys 275 Tyr
19 62 T2N0 3 ex7 G→A/p. Arg 248 Gln
20 35 T1cN0 3 ex6 A→G/p. His 193 Arg
21 54 T1cN1 3 ex7 G→A/p. Cys 242 Tyr
22 36 T2N1 3 wt -
23 48 T1cN1 3 ex6 Ins codon 213
24 56 T1cN0 3 ex5 C→A/p. Ala 161 Asp
25 42 T3N0 3 ex6 G→A/p. Val 216 Met
26 43 T2N0 3 ex10 G→T/p.Glu 339 STOP
27 66 T1cN0 3 ex5 Ins codon 125
28 50 T1cN0 3 ex5 G→A/p. Arg 175 His
29 41 T2N0 3 ex5 T→C/p. Ser 127 Pro
30 n.d. n.d. 3 ex6 A→G/p. Tyr 220 Cys
31 76 T2N0 3 wt -
32 72 T1cN1 3 wt -
33 67 T1cN0 3 wt -
  1. BLC, basal-like carcinoma; MBC, medullary breast carcinoma; n.d., not determined; wt, wild type; del, deletion; ins, insertion; int, intron; ex, exon; p, protein.