Table 1 Clinical and biological characteristics of patients with MBCs and BLCs
Case no. | Age (years) | TNM stage | Histoprognostic grade | TP53 status | |
|---|---|---|---|---|---|
BLC | |||||
1 | 69 | T2N0 | 3 | ex7 | G→A/p. Arg 248 Gln |
2 | 66 | T1N0 | 2 | ex5 | G→T/p. Cys 176 Phe |
3 | 60 | T2N0 | 2 | ex8 | G→A/p. Asp 281 Asn |
4 | 64 | T2N0 | 2 | int6 | Splice |
5 | 51 | T2N1a | 3 | wt | - |
6 | 62 | T1N1a | 2 | wt | - |
7 | 70 | T1N0 | 3 | ex7 | G→A/p. Gly 245 Ser |
8 | 37 | T1N0 | 2 | ex6 | C→T/p. Arg 213 STOP |
9 | 62 | T2N0 | 2 | ex6 | T→G/p. Ser 215 Arg |
10 | 60 | T2N1b | 3 | ex8 | C→T/p. Arg 282 Trp |
11 | 52 | T2N1 | 3 | ex6 | C→T/p. Arg 213 STOP |
12 | 50 | T3N1 | 3 | ex5 | G→A/p. Arg 175 His |
13 | 79 | T2N0 | 3 | ex5 | C→T/p. Ala 159 Val |
14 | 48 | T2N0 | 3 | ex10 | Del codon 333 |
15 | 42 | T1N0 | 3 | ex6 | Del codon 196 |
16 | 52 | T2N1b | 2 | wt | - |
17 | 82 | T2N0 | 3 | wt | - |
18 | 46 | T2N1a | 3 | nd | - |
19 | 51 | T2N0 | 3 | nd | - |
20 | 81 | T2N0 | 3 | ex7 | A→G/p. Tyr 236 Cys |
21 | n.d. | T2N0 | 3 | ex6 | T→C/p. Ile 195 Thr |
22 | 40 | T1cN0 | 3 | ex6 | T→G/p. Leu 194 Arg |
23 | 69 | T2N0 | 3 | ex5 | G→A/p. Arg 175 His |
24 | 69 | T2N0 | 3 | ex5 | C→A/p. Tyr 126 STOP |
25 | 55 | T2N0 | 3 | ex6 | C→T/p. Arg 213 STOP |
26 | 77 | T2N1 | 3 | ex7 | A→C/p. Thr 253 Pro |
MBC | |||||
1 | 46 | T1cN1 | 3 | ex7 | Del codon 241 |
2 | 34 | nd | 3 | ex7 | Del codon 252 |
3 | 46 | T2N0 | 3 | ex5 | G→A/p. Arg 175 His |
4 | 72 | T1cN0 | 3 | ex8 | G→A/p. Arg 280 Lys |
5 | 39 | T3N1 | 3 | wt | - |
6 | 53 | T2N0 | 3 | nd | - |
7 | 49 | T1cN0 | 3 | nd | - |
8 | 49 | T1cN0 | 3 | nd | - |
9 | 33 | T2N0 | 3 | nd | - |
10 | 63 | T2N0 | 3 | nd | - |
11 | 66 | T2N0 | 3 | nd | - |
12 | 50 | T1cN1a | 3 | nd | - |
13 | 57 | T1cN0 | 3 | ex7 | G→A/p. Arg 248 Gln |
14 | 68 | T2N0 | 3 | ex6 | C→T/p. Arg 213 STOP |
15 | 61 | T2N0 | 3 | ex6 | A→G/p. Tyr 220 Cys |
16 | 56 | T2N0 | 3 | wt | - |
17 | 58 | T2N0 | 3 | ex8 | G→A/p. Glu 286 Lys |
18 | 57 | T2N0 | 3 | ex8 | G→A/p. Cys 275 Tyr |
19 | 62 | T2N0 | 3 | ex7 | G→A/p. Arg 248 Gln |
20 | 35 | T1cN0 | 3 | ex6 | A→G/p. His 193 Arg |
21 | 54 | T1cN1 | 3 | ex7 | G→A/p. Cys 242 Tyr |
22 | 36 | T2N1 | 3 | wt | - |
23 | 48 | T1cN1 | 3 | ex6 | Ins codon 213 |
24 | 56 | T1cN0 | 3 | ex5 | C→A/p. Ala 161 Asp |
25 | 42 | T3N0 | 3 | ex6 | G→A/p. Val 216 Met |
26 | 43 | T2N0 | 3 | ex10 | G→T/p.Glu 339 STOP |
27 | 66 | T1cN0 | 3 | ex5 | Ins codon 125 |
28 | 50 | T1cN0 | 3 | ex5 | G→A/p. Arg 175 His |
29 | 41 | T2N0 | 3 | ex5 | T→C/p. Ser 127 Pro |
30 | n.d. | n.d. | 3 | ex6 | A→G/p. Tyr 220 Cys |
31 | 76 | T2N0 | 3 | wt | - |
32 | 72 | T1cN1 | 3 | wt | - |
33 | 67 | T1cN0 | 3 | wt | - |