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Table 5 Mean percentage mammographic density (MD) according to IGFBP-1 and IGFBP-3 haplotype-tagging SNPs

From: Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study

SNP Genotype n Mean percentage MDa p for trendb
15 G/G 120 26.4 0.39
  A/G 452 27.3  
  A/A 548 26.2  
16 A/A 36 24.0 0.41
  A/G 377 28.0  
  G/G 707 26.3  
17 G/G 56 25.3 0.75
  C/G 405 26.9  
  C/C 635 26.5  
18 A/A 1 11.9 0.18
  A/G 59 23.8  
  G/G 1,060 26.9  
19 A/A 158 28.4 0.006
  G/A 543 27.3  
  G/G 409 24.8  
20 T/T 5 21.7 0.06
  C/T 97 23.6  
  C/C 1,017 27.0  
21 G/G 120 28.2 0.81
  A/G 502 25.6  
  A/A 465 27.3  
22 T/T 108 28.1 0.44
  C/T 441 27.1  
  C/C 557 26.3  
23 T/T 35 28.2 0.67
  C/T 336 26.9  
  C/C 715 26.5  
24 A/A 195 24.8 0.55
  A/G 517 27.4  
  G/G 378 26.5  
25 C/C 148 25.5 0.86
  G/C 511 27.0  
  G/G 383 26.3  
26 T/T 202 26.4 0.87
  T/G 605 26.2  
  G/G 282 26.5  
27 T/T 49 23.4 0.80
  T/G 362 27.4  
  G/G 673 26.4  
28 A/A 47 27.6 0.65
  T/A 359 26.2  
  T/T 700 26.9  
29 C/C 44 24.0 0.16
  T/C 346 26.2  
  T/T 706 27.1  
  1. IGFBP, insulin-like growth factor binding protein. aMultivariate-adjusted models including age (continuous), body mass index (continuous), alcohol consumption (category), age at first birth/parity, history of benign breast disease (yes/no), family history of breast cancer (yes/no), menopausal status/postmenopausal hormone use (premenopausal, postmenopausal never user, postmenopausal current user, postmenopausal past user); b p for trend based on inclusion of genotype as an ordinal variable in models with square-root-transformed mammographic density as the dependent variable. The result in bold is significant (p ≤ 0.05).