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Table 2 Cytokines are present at high levels in ER-negative and PR-negative breast tumors

From: Oestrogen receptor negative breast cancers exhibit high cytokine content

Biological marker ER negative (n = 45) ER positive (n = 60) P PR negative (n = 30) PR positive (n = 75) P
IL-1β 3.7 (0–260) 2.2 (0–42.4) 0.031 5.3 (0–194) 2.3 (0–260) 0.008
IL-2 1.7 (0–42.6) 0.9 (0–11.0) 0.003 1.7 (0–6.6) 1.2 (0–42.6) 0.119
IL-4 3.8 (0–20.0) 1.1 (0–99.6) NS 4.6 (0–18.7) 1.1 (0–99.6) 0.040
IL-6 25.4 (7.8–26,487) 13.2 (4.4–619) < 0.001 53.6 (9.9–26,487) 13.7 (4.4–4,312) < 0.001
IL-8 158 (5.0–15,890) 40.5 (0–10,298) < 0.001 505 (7.3–15,890) 48.7 (0–11,281) < 0.001
IL-10 0.6 (0–5.6) 0.2 (0–2.86) 0.003 0.8 (0–5.0) 0.2 (0–5.6) < 0.001
IL-12 (p70) 3.0 (0 -19.3) 2.0 (0–17.2) 0.029 3.1 (0–7.3) 2.0 (0–19.3) 0.024
IL-13 4.3 (3.4–52.6) 4.1 (1.6–394) 0.049 4.3 (3.6–35.5) 4.1 (1.6–394) NS
G-CSF 17.3 (7.1–110) 20.1 (5.3–87.3) NS 24.1 (7.1–110) 17.4 (5.3–103) 0.056
IFN-γ 32.6 (19.4–324) 25.6 (15.5–1,279) < 0.001 33.8 (23.7–324) 25.6 (15.5–1,279) 0.002
MCP-1 210 (14.7–37,117) 80.7 (0–1,543) < 0.001 404 (17.7–37,717) 96.3 (0–1,543) < 0.001
MIP-1β 748 (42.6–14,439) 488 (87.2–10,244) 0.005 1121 (44.6–13,287) 493 (42.6–14,439) 0.001
TNF-α 8.5 (6.1–80.0) 6.9 (5.8–120) < 0.001 8.6 (6.2–37.2) 7.1 (5.8–121) 0.002
  1. Values are expressed as median (range; fg/μg). G-CSF, granulocyte colony-stimulating factor; IL, interleukin; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; NS, not significant; TNF, tumour necrosis factor.