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Table 2 Characteristics of the ATM, CHEK2 and ERBB2 tagSNPs and their association with breast cancer survival

From: Comprehensive analysis of the ATM, CHEK2 and ERBB2genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study

SNP ID SNP name Number of cases/controls Minor allele frequencya Breast cancer deaths/person-yearsb HR (95% CI)b,c
ATM      
TAG1d rs4987886 1,220/1,440 0.06 70/10,660 0.86 (0.42–1.76)
TAG2d rs3092991 1,119/1,318 0.14 65/9,717 1.12 (0.71–1.77)
TAG3d rs1800057 1,144/1,346 0.03 66/9,958 0.62 (0.16–2.46)
TAG4 rs1801516 1538/1,500 0.15 185/12,421 0.99 (0.75–1.30)
TAG5 rs17107917 1,546/1,493 0.04 192/12,466 1.01 (0.63–1.64)
TAG6d rs227060 1,152/1,350 0.28 68/10,004 0.77 (0.52–1.14)
TAG7d rs664143 1,227/1,408 0.48 73/10,684 1.24 (0.89–1.73)
CHEK2      
TAG1 rs8135424 1,539/1,478 0.13 197/12,367 1.08 (0.83–1.41)
TAG2 rs5762749 1,516/1,472 0.35 191/12,172 0.78 (0.62–0.97)
TAG3 rs743185 1,547/1,491 0.12 192/12,471 1.21 (0.91–1.62)
TAG4 rs738722 1,501/1,444 0.25 187/12,083 0.72 (0.56–0.93)
TAG5 rs5762765 1,510/1,456 0.38 192/12,118 1.15 (0.94–1.41)
TAG6 rs2236142 1,541/1,471 0.31 192/12,398 1.25 (1.02–1.54)
ERBB2      
TAG1 rs2643195 1,494/1,458 0.32 186/12,052 1.09 (0.88–1.35)
TAG2 rs4252596 1,530/1,481 0.13 189/12,330 0.95 (0.70–1.30)
TAG3 rs2952155 1,459/1,407 0.25 184/11,666 1.02 (0.80–1.29)
TAG4 rs2952156 1,546/1,481 0.32 194/12,445 1.11 (0.89–1.37)
TAG5e rs1801200e 1,548/1,485 0.26 193/12,463 1.00 (0.80–1.25)
TAG6 rs4252665 1,527/1,486 0.05 182/12,401 0.76 (0.45–1.27)
TAG7 rs3809717 1,532/1,478 0.31 194/12,310 0.96 (0.77–1.20)
  1. aIn controls.
  2. bAmong women with breast cancer.
  3. cHRs are assessed assuming co-dominance and show the increase/decrease in risk of death from breast cancer with each addition of the minor allele compared with homozygotes of the major allele.
  4. dNot genotyped in the patients who participated through tissue sample donation.
  5. eAlso named I655V.
  6. ATM, ataxia-telangiectasia mutated; CHEK2, checkpoint kinase 2; CI, confidence interval; ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; HR, hazard ratio; SNP, single nucleotide polymorphism; tagSNP, haplotype-tagging SNP.