Comprehensive analysis of the ATM, CHEK2 and ERBB2genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study

Table 2 Characteristics of the ATM, CHEK2 and ERBB2 tagSNPs and their association with breast cancer survival

SNP ID	SNP name	Number of cases/controls	Minor allele frequency^a	Breast cancer deaths/person-years^b	HR (95% CI)^b,c
ATM
TAG1^d	rs4987886	1,220/1,440	0.06	70/10,660	0.86 (0.42–1.76)
TAG2^d	rs3092991	1,119/1,318	0.14	65/9,717	1.12 (0.71–1.77)
TAG3^d	rs1800057	1,144/1,346	0.03	66/9,958	0.62 (0.16–2.46)
TAG4	rs1801516	1538/1,500	0.15	185/12,421	0.99 (0.75–1.30)
TAG5	rs17107917	1,546/1,493	0.04	192/12,466	1.01 (0.63–1.64)
TAG6^d	rs227060	1,152/1,350	0.28	68/10,004	0.77 (0.52–1.14)
TAG7^d	rs664143	1,227/1,408	0.48	73/10,684	1.24 (0.89–1.73)
CHEK2
TAG1	rs8135424	1,539/1,478	0.13	197/12,367	1.08 (0.83–1.41)
TAG2	rs5762749	1,516/1,472	0.35	191/12,172	0.78 (0.62–0.97)
TAG3	rs743185	1,547/1,491	0.12	192/12,471	1.21 (0.91–1.62)
TAG4	rs738722	1,501/1,444	0.25	187/12,083	0.72 (0.56–0.93)
TAG5	rs5762765	1,510/1,456	0.38	192/12,118	1.15 (0.94–1.41)
TAG6	rs2236142	1,541/1,471	0.31	192/12,398	1.25 (1.02–1.54)
ERBB2
TAG1	rs2643195	1,494/1,458	0.32	186/12,052	1.09 (0.88–1.35)
TAG2	rs4252596	1,530/1,481	0.13	189/12,330	0.95 (0.70–1.30)
TAG3	rs2952155	1,459/1,407	0.25	184/11,666	1.02 (0.80–1.29)
TAG4	rs2952156	1,546/1,481	0.32	194/12,445	1.11 (0.89–1.37)
TAG5^e	rs1801200^e	1,548/1,485	0.26	193/12,463	1.00 (0.80–1.25)
TAG6	rs4252665	1,527/1,486	0.05	182/12,401	0.76 (0.45–1.27)
TAG7	rs3809717	1,532/1,478	0.31	194/12,310	0.96 (0.77–1.20)

^aIn controls.
^bAmong women with breast cancer.
^cHRs are assessed assuming co-dominance and show the increase/decrease in risk of death from breast cancer with each addition of the minor allele compared with homozygotes of the major allele.
^dNot genotyped in the patients who participated through tissue sample donation.
^eAlso named I655V.
ATM, ataxia-telangiectasia mutated; CHEK2, checkpoint kinase 2; CI, confidence interval; ERBB2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; HR, hazard ratio; SNP, single nucleotide polymorphism; tagSNP, haplotype-tagging SNP.

ISSN: 1465-542X