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Table 1 Characteristics of the breast cancer cases in the parent study and the present genetic study

From: Comprehensive analysis of the ATM, CHEK2 and ERBB2genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study

  Parent study Present study Present study
Characteristic n (%) n (%) Breast cancer deathsa Mortality rateb
Total cases 2,817 1,579 198 0.016
Tumour size (mm)     
≤20 1,858 (71.4) 1,087 (73.6) 100 0.010
21–30 489 (18.8) 270 (18.3) 57 0.026
>30 254 (9.8) 120 (8.1) 38 0.043
Unknown 216 102 3 0.022
P valuec   0.13   
TNM stage     
1 1,392 (54.4) 804 (55.3) 40 0.006
2 1,074 (42.0) 606 (41.7) 126 0.026
3 58 (2.3) 31 (2.1) 15 0.076
4 34 (1.3) 12 (0.8) 11 0.262
Unknown 259 126 6 0.019
P valuec   0.39   
Lymph-node involvement     
No 1,741 (68.2) 1,002 (68.9) 68 0.008
Yes 813 (31.8) 453 (31.1) 122 0.035
Unknown 263 124 8 0.027
P valuec   0.23   
Grade     
1 259 (14.7) 143 (14.2) 4 0.003
2 739 (41.9) 444 (44.1) 37 0.010
3 766 (43.4) 419 (41.7) 93 0.027
Unknown 1,053 573 64 0.016
P valuec   0.61   
Oestrogen and progesterone receptor status     
ER+/PR+ 1,162 (62.7) 677 (65.4) 72 0.012
ER+/PR- 285 (15.4) 133 (12.9) 28 0.026
ER-/PR+ 69 (3.7) 33 (3.2) 7 0.027
ER-/PR- 338 (18.2) 192 (18.6) 52 0.037
Unknown 963 544 39 0.010
P valuec   0.37   
Histological type     
Ductal 1,891 (72.5) 1,070 (72.4) 147 0.016
Lobular 304 (11.7) 185 (12.5) 19 0.012
Other 414 (15.9) 223 (15.1) 28 0.014
Unknown 208 101 4 0.039
P valuec   0.48   
S-phase fraction     
Low 689 (68.1) 401 (70.0) 40 0.011
High 323 (31.9) 172 (30.0) 52 0.040
Unknown 1805 1,006 106 0.013
P valuec   0.71   
  1. aFrom the date of diagnosis until 31 December 2003.
  2. bFrom the date of diagnosis until 31 December 2003 or until the date of death or emigration, whichever came first. Calculated as breast cancer deaths per person-year of follow-up.
  3. cChi-squared test of independence between the parent and the present studies.
  4. ER, oestrogen receptor; PR, progesterone receptor