Predicting a local recurrence after breast-conserving therapy by gene expression profiling

Breast Cancer Research

Table 3 Performance of three different supervised analyses on validation series

Analysis	WS supervised	70-genes supervised	Hypoxia supervised
Sensitivity (percentage)	88	63	75
Specificity (percentage)	74	50	44
Low risk/high risk^a (percentage)	67/33	49/51	42/58
10-year LC low/high (percentage)	95/71	87/86	87/85
p ^b	0.0008	0.34	0.4

WS, wound signature; LC, local control.
^aIn validation set (percentages; n = 80); ^b p value in validation set (log-rank).

ISSN: 1465-542X