Table 5 List of 78 genes able to discriminate between well/well-intermediately and intermediately-poorly/poorly differentiated DCIS
From: Classification of ductal carcinoma in situ by gene expression profiling
Rank | NKI ID | Symbol | Annotation | Accession no. |
|---|---|---|---|---|
1 | 111275 | Â | EST | H20757 |
2 | 109268 | ALDH3A2 | Aldehyde dehydrogenase 3 family, member A2 | AA633569 |
3 | 109236 | BTD | Biotinidase | R17765 |
4 | 110384 | KPNA2 | Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | AA676460 |
5 | 131448 | PLEKHG1 | KIAA1209 protein | AI301815 |
6 | 108691 | ACK1 | Activated p21cdc42Hs kinase | AA427891 |
7 | 107840 | EPC1 | ESTs | AA120875 |
8 | 126868 | TMC4 | DKFZP586J0619 protein | AA991211 |
9 | 106257 | FLJ32499 | H. sapiens cDNA FLJ12749 fis, clone NT2RP2001149 | W56590 |
10 | 128493 | GMFG | Glia maturation factor, gamma | AI311932 |
11 | 128702 | Â | Â | AI313031 |
12 | 129547 | METAP2 | Methionine aminopeptidase; eIF-2-associated p67 | AA283030 |
13 | 111787 | ZNF451 | H. sapiens cDNA FLJ13010 fis, clone NT2RP3000542 | AA486412 |
14 | 103209 | RBMS1 | H. sapiens mRNA; cDNA DKFZp564H0764 (from clone DKFZp564H0764) | R62566 |
15 | 108595 | CCL19 | Small inducible cytokine subfamily A (Cys-Cys), member 19 | AA680186 |
16 | 129267 | Â | Â | AA609203 |
17 | 109127 | ESR1 | Oestrogen receptor 1 | AA291749 |
18 | 100263 | MYB | V-myb avian myeloblastosis viral oncogene homolog | N49284 |
19 | 100524 | CELSR2 | Cadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog | H39187 |
20 | 100260 | MAL | Mal, T-cell differentiation protein | AA227885 |
21 | 102995 | PIGT | CGI-06 protein | H82992 |
22 | 108649 | Â | Human clone 23948 mRNA sequence | H15114 |
23 | 109246 | BCL2 | B-cell CLL/lymphoma 2 | W63749 |
24 | 100203 | TNFAIP3 | Tumour necrosis factor, alpha-induced protein 3 | AA476272 |
25 | 107809 | XBP1 | X-box binding protein 1 | W90128 |
26 | 102921 | Â | H. sapiens mRNA; cDNA DKFZp434D0818 (from clone DKFZp434D0818) | N95578 |
27 | 108671 | BCAT2 | Branched chain aminotransferase 2, mitochondrial | AA436410 |
28 | 101925 | EZH2 | Â | AA430744 |
29 | 123382 | HIG1 | Likely ortholog of mouse hypoxia induced gene 1 | T74105 |
30 | 131187 | KPNA2 | Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | AA489087 |
31 | 111288 | Â | H. sapiens mRNA; cDNA DKFZp564C2063 (from clone DKFZp564C2063) | AA416628 |
32 | 109170 | C4A | Complement component 4A | AA664406 |
33 | 108203 | TEGT | Testis enhanced gene transcript (BAX inhibitor 1) | AA629591 |
34 | 102639 | EML2 | Microtubule-associated protein like echinoderm EMAP | R27580 |
35 | 131258 | PSMA7 | Proteasome (prosome, macropain) subunit, alpha type, 7 | AI318565 |
36 | 123478 | FLJ14712 | Hypothetical protein FLJ14712 | N79050 |
37 | 109415 | FCGBP | Fc fragment of IgG binding protein | R52030 |
38 | 127815 | PLAT | Plasminogen activator, tissue | R38933 |
39 | 115769 | Â | ESTs | AA406313 |
40 | 106220 | GIMAP5 | Hypothetical protein FLJ11296 | AA150443 |
41 | 128641 | PTTG1 | Pituitary tumour-transforming 1 | AI362866 |
42 | 105439 | TGOLN2 | Trans-Golgi network protein (46-, 48-, 51-kD isoforms) | T81338 |
43 | 101362 | ERBB2 | V-erb-b2 avian erythroblastic leukaemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) | AA446928 |
44 | 108387 | IDH2 | Isocitrate dehydrogenase 2 (NADP+), mitochondrial | AA679907 |
45 | 100352 | TGOLN2 | Trans-Golgi network protein (46-, 48-, 51-kD isoforms) | H82891 |
46 | 107941 | PLAC8 | Hypothetical protein | AA150263 |
47 | 100104 | SELL | Selectin L (lymphocyte adhesion molecule 1) | H00662 |
48 | 110983 | DLEU1 | Deleted in lymphocytic leukaemia, 1 | AA425755 |
49 | 108438 | GRB7 | Growth factor receptor-bound protein 7 | H53703 |
50 | 107752 | PAG | Phosphoprotein associated with GEMs | N50114 |
51 | 128532 | LTB | Lymphotoxin beta (TNF superfamily, member 3) | AI351740 |
52 | 124620 | ASTN2 | KIAA0634 protein | AA404602 |
53 | 102357 | CHN1 | Chimerin (chimaerin) 1 | AA598668 |
54 | 109454 | AKR7A2 | Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | T62865 |
55 | 108678 | CASP10 | Caspase 10, apoptosis-related cysteine protease | H80712 |
56 | 131111 | CUGBP2 | CUG triplet repeat, RNA-binding protein 2 | AA047257 |
57 | 123475 | C9orf87 | Hypothetical protein FLJ10493 | N53432 |
58 | 105013 | Â | EST | H61003 |
59 | 100791 | TDG | Thymine-DNA glycosylase | AA496947 |
60 | 100528 | BCL2L2 | BCL2-like 2 | AA454588 |
61 | 116312 | FLJ14299 | Hypothetical protein FLJ14299 | AA453170 |
62 | 100700 | TRIB2 | GS3955 protein | AA458653 |
63 | 102004 | PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | R54050 |
64 | 104569 | MYO1B | H. sapiens cDNA FLJ20153 fis, clone COL08656, highly similar to AJ001381 H. sapiens incomplete cDNA for a mutated allele | N95358 |
65 | 113907 | SNRPB2 | Small nuclear ribonucleoprotein polypeptide B" | H00286 |
66 | 128683 | WASL | Wiskott-Aldrich syndrome-like | AI261600 |
67 | 123768 | DUSP22 | Mitogen-activated protein kinase phosphatase x | H42417 |
68 | 105099 | RET | Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease) | H24956 |
69 | 116859 | STMN1 | Leukaemia-associated phosphoprotein p18 (stathmin) | AA873060 |
70 | 111660 | FLJ13710 | ESTs | AA120866 |
71 | 100112 | SAA1 | Serum amyloid A1 | H25546 |
72 | 100840 | THOC1 | Nuclear matrix protein p84 | AA129297 |
73 | 129239 | Â | EST, Moderately similar to AF119917 63 PRO2831 [H. sapiens] | W95750 |
74 | 115662 | GIMAP4 | Hypothetical protein FLJ11110 | AA406363 |
75 | 109607 | HTPAP | ESTs | T48412 |
76 | 108692 | EMP2 | Epithelial membrane protein 2 | T88721 |
77 | 105133 | JUNB | Jun B proto-oncogene | N94468 |
78 | 129959 | LOC283352 | EST | AI023540 |