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Table 5 List of 78 genes able to discriminate between well/well-intermediately and intermediately-poorly/poorly differentiated DCIS

From: Classification of ductal carcinoma in situ by gene expression profiling

Rank NKI ID Symbol Annotation Accession no.
1 111275   EST H20757
2 109268 ALDH3A2 Aldehyde dehydrogenase 3 family, member A2 AA633569
3 109236 BTD Biotinidase R17765
4 110384 KPNA2 Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) AA676460
5 131448 PLEKHG1 KIAA1209 protein AI301815
6 108691 ACK1 Activated p21cdc42Hs kinase AA427891
7 107840 EPC1 ESTs AA120875
8 126868 TMC4 DKFZP586J0619 protein AA991211
9 106257 FLJ32499 H. sapiens cDNA FLJ12749 fis, clone NT2RP2001149 W56590
10 128493 GMFG Glia maturation factor, gamma AI311932
11 128702    AI313031
12 129547 METAP2 Methionine aminopeptidase; eIF-2-associated p67 AA283030
13 111787 ZNF451 H. sapiens cDNA FLJ13010 fis, clone NT2RP3000542 AA486412
14 103209 RBMS1 H. sapiens mRNA; cDNA DKFZp564H0764 (from clone DKFZp564H0764) R62566
15 108595 CCL19 Small inducible cytokine subfamily A (Cys-Cys), member 19 AA680186
16 129267    AA609203
17 109127 ESR1 Oestrogen receptor 1 AA291749
18 100263 MYB V-myb avian myeloblastosis viral oncogene homolog N49284
19 100524 CELSR2 Cadherin, EGF LAG seven-pass G-type receptor 2, flamingo (Drosophila) homolog H39187
20 100260 MAL Mal, T-cell differentiation protein AA227885
21 102995 PIGT CGI-06 protein H82992
22 108649   Human clone 23948 mRNA sequence H15114
23 109246 BCL2 B-cell CLL/lymphoma 2 W63749
24 100203 TNFAIP3 Tumour necrosis factor, alpha-induced protein 3 AA476272
25 107809 XBP1 X-box binding protein 1 W90128
26 102921   H. sapiens mRNA; cDNA DKFZp434D0818 (from clone DKFZp434D0818) N95578
27 108671 BCAT2 Branched chain aminotransferase 2, mitochondrial AA436410
28 101925 EZH2   AA430744
29 123382 HIG1 Likely ortholog of mouse hypoxia induced gene 1 T74105
30 131187 KPNA2 Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) AA489087
31 111288   H. sapiens mRNA; cDNA DKFZp564C2063 (from clone DKFZp564C2063) AA416628
32 109170 C4A Complement component 4A AA664406
33 108203 TEGT Testis enhanced gene transcript (BAX inhibitor 1) AA629591
34 102639 EML2 Microtubule-associated protein like echinoderm EMAP R27580
35 131258 PSMA7 Proteasome (prosome, macropain) subunit, alpha type, 7 AI318565
36 123478 FLJ14712 Hypothetical protein FLJ14712 N79050
37 109415 FCGBP Fc fragment of IgG binding protein R52030
38 127815 PLAT Plasminogen activator, tissue R38933
39 115769   ESTs AA406313
40 106220 GIMAP5 Hypothetical protein FLJ11296 AA150443
41 128641 PTTG1 Pituitary tumour-transforming 1 AI362866
42 105439 TGOLN2 Trans-Golgi network protein (46-, 48-, 51-kD isoforms) T81338
43 101362 ERBB2 V-erb-b2 avian erythroblastic leukaemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) AA446928
44 108387 IDH2 Isocitrate dehydrogenase 2 (NADP+), mitochondrial AA679907
45 100352 TGOLN2 Trans-Golgi network protein (46-, 48-, 51-kD isoforms) H82891
46 107941 PLAC8 Hypothetical protein AA150263
47 100104 SELL Selectin L (lymphocyte adhesion molecule 1) H00662
48 110983 DLEU1 Deleted in lymphocytic leukaemia, 1 AA425755
49 108438 GRB7 Growth factor receptor-bound protein 7 H53703
50 107752 PAG Phosphoprotein associated with GEMs N50114
51 128532 LTB Lymphotoxin beta (TNF superfamily, member 3) AI351740
52 124620 ASTN2 KIAA0634 protein AA404602
53 102357 CHN1 Chimerin (chimaerin) 1 AA598668
54 109454 AKR7A2 Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) T62865
55 108678 CASP10 Caspase 10, apoptosis-related cysteine protease H80712
56 131111 CUGBP2 CUG triplet repeat, RNA-binding protein 2 AA047257
57 123475 C9orf87 Hypothetical protein FLJ10493 N53432
58 105013   EST H61003
59 100791 TDG Thymine-DNA glycosylase AA496947
60 100528 BCL2L2 BCL2-like 2 AA454588
61 116312 FLJ14299 Hypothetical protein FLJ14299 AA453170
62 100700 TRIB2 GS3955 protein AA458653
63 102004 PIK3R1 Phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) R54050
64 104569 MYO1B H. sapiens cDNA FLJ20153 fis, clone COL08656, highly similar to AJ001381 H. sapiens incomplete cDNA for a mutated allele N95358
65 113907 SNRPB2 Small nuclear ribonucleoprotein polypeptide B" H00286
66 128683 WASL Wiskott-Aldrich syndrome-like AI261600
67 123768 DUSP22 Mitogen-activated protein kinase phosphatase x H42417
68 105099 RET Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease) H24956
69 116859 STMN1 Leukaemia-associated phosphoprotein p18 (stathmin) AA873060
70 111660 FLJ13710 ESTs AA120866
71 100112 SAA1 Serum amyloid A1 H25546
72 100840 THOC1 Nuclear matrix protein p84 AA129297
73 129239   EST, Moderately similar to AF119917 63 PRO2831 [H. sapiens] W95750
74 115662 GIMAP4 Hypothetical protein FLJ11110 AA406363
75 109607 HTPAP ESTs T48412
76 108692 EMP2 Epithelial membrane protein 2 T88721
77 105133 JUNB Jun B proto-oncogene N94468
78 129959 LOC283352 EST AI023540
  1. DCIS, ductal carcinoma in situ; EST, expressed sequence tag; NKI ID, Netherlands Cancer Institute (Amsterdam, The Netherlands) identification number.