Table 2 Genes that are either upregulated or downregulated by B-10
From: Anti-erbB2 treatment induces cardiotoxicity by interfering with cell survival pathways
Gene | Up/downa |
|---|---|
Mitogen-activated protein kinase 9 (MAPK9; PRKM9); c-jun N-terminal kinase 2 (JNK2); stress-activated protein kinase alpha (SAPK-α) | ↑ |
Heat shock 27-kDa protein (HSP27) | ↑ |
Heat shock 90-kDa protein beta (HSP90-β); HSP84; HSPCB | ↑ |
Heat shock 60-kDa protein (HSP60); 60-kDa chaperonin (CPN60); GroEL homolog; mitochondrial matrix protein P1; p60 lymphocyte protein | ↑ |
Heat shock 47-kDa protein (HSP47); collagen-binding protein 1 (CBP1) | ↓ |
HSP70/HSP90-organizing protein (HOP); p60 protein | ↓ |
Heat shock 10-kDa protein (HSP10); chaperonin 10 (CPN10) | ↓ |
p23; 23-kDa progesterone receptor-associated protein (rat homologue of human) | ↓ |
Vimentin (VIM) | ↑ |
T-complex protein 1 alpha subunit (TCP1-α); CCT-alpha (CCTA; CCT1) | ↓ |
T-complex protein 1 eta subunit (TCP1-eta); CCT-eta (CCTH; CCT7); HIV-1 NEF interacting protein (rat homologue of human) | ↑ |
Calreticulin (CALR); calregulin; calcium-binding protein 3 (CABP3); HACBP; ERP60 | ↑ |
Endoplasmic reticulum stress protein 72 (ERP72); calcium-binding protein 2 (CABP2) | ↓ |
M-phase inducer phosphatase 2 (MPI2); cell division control protein 25 B (CDC25B) | ↓ |
G1/S-specific cyclin D2 (CCND2); vin-1 proto-oncogene | ↑ |
G1/S-specific cyclin D3 (CCND3) | ↓ |
G2/M-specific cyclin G (CCNG) | ↑ |
Inhibitor of DNA binding 1 (ID1) | ↑ |
Inhibitor of DNA binding 2 (ID2) | ↓ |
Prothymosin-alpha (PTMA) | ↑ |
Soluble superoxide dismutase 1 (SOD1) | ↓ |
DNA topoisomerase I (TOP1; rat homologue of human) | ↑ |
Nucleophosmin (NPM); nucleolar phosphoprotein B23; numatrin; nucleolar protein NO38 | ↓ |
Ribosomal protein S19 (RPS19) | ↓ |