Table 1 Association between BRCA1 methylation and AI at the BRCA loci and other tumor features
From: Epigenetic silencing and deletion of the BRCA1gene in sporadic breast cancer
Primary sporadic breast tumours | BRCA1 promoter methylation | P value | |
|---|---|---|---|
| Â | Yes (n = 13) | No (n = 130) | Â |
AI at the BRCA1 locus | Â | Â | Â |
   Yes | 8 (62%) | 41 (35%) |  |
   No | 5 (38%) | 77 (65%) | 0.0731 |
   ND/NA |  | 12 |  |
AI at the BRCA2 locus | Â | Â | Â |
   Yes | 5 (38%) | 37 (30%) |  |
   No | 8 (62%) | 85 (70%) | 0.5420 |
   ND/NA |  | 8 |  |
TP53 mutations | Â | Â | Â |
   Mutated TP53 gene | 5 (38%) | 22 (17%) |  |
   Wild type | 8 (62%) | 106 (83%) | 0.1299 |
   ND/NA |  | 2 |  |
Estrogen receptor | Â | Â | Â |
   Negative | 7 (54%) | 33 (25%) |  |
   Positive | 6 (46%) | 97 (75%) | 0.0475 |
   ND/NA |  |  |  |
Progesterone receptor | Â | Â | Â |
   Negative | 6 (50%) | 57 (44%) |  |
   Positive | 6 (50%) | 72 (56%) | 0.7699 |
   ND/NA | 1 | 1 |  |
Age at diagnosis | Â | Â | Â |
   ≤ 55 years | 9 (69%) | 57(44%) |  |
   >55 years | 4 (31%) | 73 (56%) | 0.0898 |