Volume 8 Supplement 1

Symposium Mammographicum 2006

Open Access

Radiotherapy for screen-detected ductal carcinoma in situ: indications and utilization in the United Kingdom – findings from the Sloane Project

  • D Dodwell1,
  • K Clements2,
  • WD George3,
  • G Lawrence2 and
  • H Bishop4
Breast Cancer Research20068(Suppl 1):P51

https://doi.org/10.1186/bcr1466

Published: 10 July 2006

There is an increasing use of wide local excision (WLE) in preference to mastectomy as the definitive surgical therapy. A number of randomised control trials (RCTs) have confirmed that postoperative whole-breast breast irradiation (RT) following WLE of DCIS reduces the risk of in situ and invasive recurrence. Available RCTs do not readily allow the identification of patients who would benefit most from RT, or conversely do not require RT.

Of 870 patients who underwent WLE for DCIS, 453 were referred for RT. The use of RT following WLE was correlated with pathological characteristics and margin status. The use of RT varied with tumour size, nuclear grade and the presence of necrosis, but not with margin size. There was a good correlation with Van Nuys Score, supporting the use of this scoring system in routine practice to predict the potential benefits of referral for RT.

Table 1

 

Received radiotherapy

Did not receive radiotherapy

Margin

  

   <1 mm

34

36

   1–9 mm

152

111

   ≥10 mm

129

100

Size

  

   ≤15 mm

161

213

   16–40 mm

153

58

   ≥41 mm

14

5

Grade

  

   High

243

95

   Intermediate

83

126

   Low

12

57

Authors’ Affiliations

(1)
Cookridge Hospital
(2)
West Midlands Cancer Intelligence Unit
(3)
Western General Infirmary
(4)
Royal Bolton Hospital

Copyright

© BioMed Central 2006

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