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Archived Comments for: Variation in the RAD51 gene and familial breast cancer

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  1. Importance of Familial and inherited breast cancers in preventive paradigm.

    Parvin Mehdipour, Department of Med. Genetics, School of Medicine, Tehran University of Medical Sciences

    13 June 2006

    Many thanks for the valuable contribution to the breast cancer word.

    You have written the following description in the Introduction:" ..other 90–95% is assumed to be 'sporadic', with no apparent family history. A large proportion of familial breast cancer (<40%) can be attributed to mutations in the high-risk genes BRCA1 and BRCA2 [1]".

    My comment: the sporadic figure of 90%-95% doesn't indicate that the proband has no family history.There are many families in my database having 3-8 and 4-12 relatives affected with Breast cancer and other malignancies, respectively, who had no mutation in BRCA1&2.So, Familial BC is not representive of inherited BC. Many of our early onset probands with no family history could be positive ( i.e.,inherited, or new mutation)or negative for BRCA-genes.

    Many thanks

    Parvin Mehdipour

    Parvin Mehdipour,MSc,PhD

    Professor and Chief,

    Unit of Cancer Genetics and Cytogenetics,

    And deputy of educational affair,

    Department of Medical Genetics,

    Faculty of Medicine,

    Tehran University of Medical sciences,

    Tehran 14155-6447

    IR Iran


    Competing interests

    The global movement for achieving more complementary data on the Gentic aspects of breast cancer patients required the followings:

    -Linking between available datas from different populations in the world.

    -Creating a core for discussion between the scientists who are actively involved in breast cancer resaerch.