Index | Day 0 | Day 14 | Day 21 | Day 28 | |||
---|---|---|---|---|---|---|---|
Control | R115777 | Control | R115777 | Control | R115777 | ||
Overall effect | |||||||
Ki67 (%) | 27.1 (19.3–32.9) | 9.4 (7.2–12.2) | 10.3 (7.7–13.9) | 13.2 (9.2–18.9) | 7.5* (5.4–10.6) | 11.8 (7.7–18.2) | 8.4 (7.2–8.2) |
Apoptosis (%) | 3.7 (3.5–4.2) | 2.8 (1.5–5.2) | 3.3 (2.1–5.1) | 2.7 (1.8–4.1) | 3.2 (2.0–5.4) | 2.5 (1.5–3.9) | 3.8** (2.7–5.2) |
CTI | 6.2 (5.2–9.1) | 2.8 (1.5–5.1) | 3.5 (2.0–6.3) | 6.2 (3.8–10.3) | 2.6** (1.4–5.0) | 3.9 (2.6–6.1) | 2.4 (1.8–3.1) |
R115777 100 mg/kg | |||||||
Ki67 (%) | 27.1 (19.3–32.9) | 8.4 (5.8–12.3) | 8.7 (6.1–12.3) | 12.8 (7.6–21.5) | 6.2*** (4.5–8.7) | 12.1 (6.5–22.4) | 8.7 (7.2–10.5) |
Apoptosis (%) | 3.7 (3.5–4.2) | 3.3 (1.2–9.1) | 3.7 (1.8–7.5) | 3.0 (1.8–5.2) | 3.9 (2.1–7.4) | 2.9 (1.4–6.0) | 4.1 (2.5–6.7) |
CTI | 6.2 (5.2–9.1) | 1.8 (1.2–2.7) | 2.5 (1.8–3.6) | 4.8 (3.8–6.0) | 1.9*** (1.4–2.5) | 3.2 (2.5–4.1) | 2.3 (1.5–3.6) |
R115777 50 mg/kg | |||||||
Ki67 (%) | 27.1 (19.3–32.9) | 11.8 (7.0–19.7) | 13.9 (10.1–18.9) | 14.0 (4.3–45.6) | 11.1 (7.2–17.1) | 11.1 (3.3–37.3) | 7.9 (5.2–12.1) |
Apoptosis (%) | 3.7 (3.5–4.2) | 2.1 (0.8–5.9) | 2.6 (1.1–6.1) | 2.3 (0.8–6.7) | 2.3 (0.6–8.8) | 1.9 (0.8–4.3) | 3.2* (1.5–6.8) |
CTI | 6.2 (5.2–9.1) | 5.9 (3.1–11.2) | 6.1 (2.2–16.7) | 9.2 (3.7–23.1) | 6.2 (2.1–18.5) | 6.3 (2.2–18.6) | 2.4 (1.4–4.1) |