Spontaneous and therapeutic abortions and the risk of breast cancer among BRCAmutation carriers

Breast Cancer Research

Table 4 Spontaneous abortions among affected and unaffected BRCA mutation carriers

Number of spontaneous abortions	Cases	Controls	OR (95% CI)	P value
BRCA1 carriers
Never	1,022	1,032	1
Ever	291	281	1.09 (0.89–1.32)	0.42
1	210	195	1.14 (0.90–1.43)	0.28
2	53	59	0.94 (0.63–1.42)	0.77
3+	28	27	1.05 (0.61–1.81)	0.86
Mean	0.32	0.31		0.70
BRCA2 carriers
Never	295	266	1
Ever	85	114	0.75 (0.55–1.04)	0.09
1	58	83	0.71 (0.48–1.04)	0.08
2	16	23	0.65 (0.33–1.26)	0.20
3+	11	8	1.54 (0.59–4.01)	0.38
Mean	0.35	0.41		0.30

Odds ratios adjusted for age at menarche (years), parity (0, 1, 2, 3, 4+), age of first birth (years), oral contraceptive use (ever/never) and oophorectomy (ever/never).

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