Table 3 Median age of onset of first diagnosis of breast or ovarian cancer in BRCA1/2 carriers and non-carriers
BRCA1 carrier of a pathogenic or splice site mutation | BRCA2 carrier of a pathogenic or splice site mutation | BRCA1 carrier of an unclassified variant | BRCA2 carrier of an unclassified variant | No identified mutations | |
|---|---|---|---|---|---|
Females with breast cancer (range) | 40 (23–70) | 42 (24–79) | 44 (22–88) | 43 (29–79) | 50 (15–90) |
Females with ovarian cancer (range) | 50 (33–80) | 56 (45–77) | none | 80 (80-80) | 55.5 (27–79) |
Females with breast and ovarian cancer (range) | 50 (26–85) | 60 (41–73) | 62.5 (55–75) | none | 53 (30–75) |
Males with breast cancer (range) | none | 68.5 (46–86) | none | none | 62 (31–75) |