Table 2 Observed and predicted number of mutations in the first screened individual by cancer status
Cancer status | Model | BRCA1 a | BRCA2 a | Noncarriers |
|---|---|---|---|---|
Unaffected | Observed | 3 | 5 | 96 |
| Â | BOADICEA | |||
|  |    Full pedigrees | 3.49 | 6.30 | 94.21 |
|  |    Second-degree relatives | 2.46 | 4.10 | 97.44 |
| Â | BRCAPRO | 10.74 | 4.20 | 89.06 |
Breast cancer | Observed | 6 | 12 | 55 |
| Â | BOADICEA | |||
|  |    Full pedigrees | 8.68 | 13.17 | 51.14 |
|  |    Second-degree relatives | 7.42 | 8.75 | 56.83 |
| Â | BRCAPRO | 26.29 | 10.90 | 36.97 |
Ovarian cancer | Observed | 5 | 2 | 4 |
| Â | BOADICEA | |||
|  |    Full pedigrees | 3.52 | 0.63 | 6.85 |
|  |    Second-degree relatives | 2.27 | 0.41 | 8.31 |
| Â | BRCAPRO | 5.12 | 0.56 | 5.32 |
Totals | Observed | 14 | 19 | 155 |
| Â | BOADICEA | |||
|  |    Full pedigrees | 15.69 | 20.10 | 152.21 |
|  |    Second-degree relatives | 12.15 | 13.26 | 162.59 |
| Â | BRCAPRO | 42.16 | 15.67 | 130.35 |