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Table 2 Observed and predicted number of mutations in the first screened individual by cancer status

From: BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families

Cancer status Model BRCA1 a BRCA2 a Noncarriers
Unaffected Observed 3 5 96
  BOADICEA
     Full pedigrees 3.49 6.30 94.21
     Second-degree relatives 2.46 4.10 97.44
  BRCAPRO 10.74 4.20 89.06
Breast cancer Observed 6 12 55
  BOADICEA
     Full pedigrees 8.68 13.17 51.14
     Second-degree relatives 7.42 8.75 56.83
  BRCAPRO 26.29 10.90 36.97
Ovarian cancer Observed 5 2 4
  BOADICEA
     Full pedigrees 3.52 0.63 6.85
     Second-degree relatives 2.27 0.41 8.31
  BRCAPRO 5.12 0.56 5.32
Totals Observed 14 19 155
  BOADICEA
     Full pedigrees 15.69 20.10 152.21
     Second-degree relatives 12.15 13.26 162.59
  BRCAPRO 42.16 15.67 130.35
  1. aNot mutually exclusive under BRCAPRO.