Breast Cancer Research

Table 1 Frequent DNA copy number alterations in breast cancer: previous reports compared with the current study

From: High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

Genomic change	Previous reports			Current study
	Reference	Region	% Tumors	Cytoband^a	Start (Mb)^a,b	Stop (Mb)^a,b	Size (Mb)^a,b	% Tumors	Cancer genes
Gains
1q+				1p36.32	2.0	6.0	4.0	49
1q+				1q23.3	158.8	159.6	0.8	57
1q+	[5-10]	1q32	48–67	1q32.1	202.1	202.9	0.8	66
1q+				1q42.12-42.13	221.8	225.9	4.1	53
4p+				4p16.1	7.1	8.8	1.7	51
5p+	[6]	5p12-14	24	5p15.33	0	1.9	1.9	49	TERT
8q+	[5-10]	8q22-qter	39–49	8q24.3	139.3	144.8	5.6	79	PTK2
9q+				9q34.13-34.3	130.5	135.2	4.6	53	TSC1 RALGDS
16p+	[6]	16p	38–40	16p13.3	3.2	3.3	0.1	57	MMP25
17q+	[6-10]	17q12	18–60	17q12	33.6	38.9	5.3	45	TAF15 MLLT6 ERBB2
17q+	[5-10]	17q22-25	18–60	17q25.3	77.7	81.1	3.5	45	GRB2 TIMP2
20q+	[5-10]	20q13	18–44	20q13.12	43.8	45.7	1.9	49	MMP9
Losses
4q-				4q31.1-31.21	141.6	145.2	3.6	40
4q-				4q32	156.1	160.1	4.0	36
4q-				4q32.2	162.9	164.2	1.3	32
8p-	[7]	8p22-23	20	8p23.1-23.2	4.8	7.6	2.8	40
8p-	[6,8,10]	8p	18–29	8p21.3	19.9	20.0	0.1	32
				8p21.2	23.5	27.5	4.0	36	PTK2B
				8p12	34.8	35.6	0.8	32
9p-	[6,7,9]	9p22-24	20–23	9p21.2	27.6	27.9	0.3	30
13q-	[6-8,10]	13q21-31; 13q22-31	18–57	13q14.13	44.6	45.1	0.5	30	LCP1
16q-	[6-8]	16q21-qter; 16q23-24	20–38	16q21	61.5	63.5	2.0	34	CDH8
17p-				17p12	11.5	11.6	0.1	32
18p-				18p11.31-11.23	6.1	7.6	1.5	36
21q-				21q11.2-21.1	15.3	15.9	0.6	32

Regions of gain and loss identified in previous studies are shown in comparison to those regions as detected in the present study. ^aMap positions and cytogenetic locations are based on data available from UCSC genome browser (July 2003 freeze) [35]. ^bRegion boundaries were determined by the next bacterial artificial chromosome with different copy number.

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ISSN: 1465-542X

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