Skip to main content

Table 1 Frequent DNA copy number alterations in breast cancer: previous reports compared with the current study

From: High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

Genomic change Previous reports Current study
  Reference Region % Tumors Cytobanda Start (Mb)a,b Stop (Mb)a,b Size (Mb)a,b % Tumors Cancer genes
Gains          
1q+     1p36.32 2.0 6.0 4.0 49  
1q+     1q23.3 158.8 159.6 0.8 57  
1q+ [5-10] 1q32 48–67 1q32.1 202.1 202.9 0.8 66  
1q+     1q42.12-42.13 221.8 225.9 4.1 53  
4p+     4p16.1 7.1 8.8 1.7 51  
5p+ [6] 5p12-14 24 5p15.33 0 1.9 1.9 49 TERT
8q+ [5-10] 8q22-qter 39–49 8q24.3 139.3 144.8 5.6 79 PTK2
9q+     9q34.13-34.3 130.5 135.2 4.6 53 TSC1 RALGDS
16p+ [6] 16p 38–40 16p13.3 3.2 3.3 0.1 57 MMP25
17q+ [6-10] 17q12 18–60 17q12 33.6 38.9 5.3 45 TAF15 MLLT6 ERBB2
17q+ [5-10] 17q22-25 18–60 17q25.3 77.7 81.1 3.5 45 GRB2 TIMP2
20q+ [5-10] 20q13 18–44 20q13.12 43.8 45.7 1.9 49 MMP9
Losses          
4q-     4q31.1-31.21 141.6 145.2 3.6 40  
4q-     4q32 156.1 160.1 4.0 36  
4q-     4q32.2 162.9 164.2 1.3 32  
8p- [7] 8p22-23 20 8p23.1-23.2 4.8 7.6 2.8 40  
8p- [6,8,10] 8p 18–29 8p21.3 19.9 20.0 0.1 32  
     8p21.2 23.5 27.5 4.0 36 PTK2B
     8p12 34.8 35.6 0.8 32  
9p- [6,7,9] 9p22-24 20–23 9p21.2 27.6 27.9 0.3 30  
13q- [6-8,10] 13q21-31; 13q22-31 18–57 13q14.13 44.6 45.1 0.5 30 LCP1
16q- [6-8] 16q21-qter; 16q23-24 20–38 16q21 61.5 63.5 2.0 34 CDH8
17p-     17p12 11.5 11.6 0.1 32  
18p-     18p11.31-11.23 6.1 7.6 1.5 36  
21q-     21q11.2-21.1 15.3 15.9 0.6 32  
  1. Regions of gain and loss identified in previous studies are shown in comparison to those regions as detected in the present study. aMap positions and cytogenetic locations are based on data available from UCSC genome browser (July 2003 freeze) [35]. bRegion boundaries were determined by the next bacterial artificial chromosome with different copy number.