From: A prospective study of XRCC1(X-ray cross-complementing group 1) polymorphisms and breast cancer risk
Polymorphism | Never smokers | Ever smokers |
---|---|---|
Arg194Trp | ||
   Arg/Arg | ||
No. of cases/no. of controls | 217/237 | 216/175 |
ORa (95% CI) | 1.00 (ref.) | 1.00 (ref.) |
   Arg/Trp or Trp/Trp | ||
No. of cases/no. of controls | 26/36 | 21/32 |
ORa (95% CI) | 0.78 (0.43–1.40) | 0.47 (0.24–0.94) |
 | Interaction p = 0.28 | |
Arg399Gln | ||
   Arg/Arg | ||
No. of cases/no. of controls | 107/104 | 88/88 |
ORa (95% CI) | 1.00 (ref.) | 1.00 (ref.) |
   Arg/Gln | ||
No. of cases/no. of controls | 100/112 | 92/89 |
ORa (95% CI) | 0.91 (0.57–1.43) | 1.06 (0.66–1.72) |
   Gln/Gln | ||
No. of cases/no. of controls | 23/35 | 38/20 |
ORa (95% CI) | 0.64 (0.33–1.26) | 2.76 (1.36–5.63) |
 | Interaction p = 0.01 |