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Table 2 Conditional logistic regression models examining XRCC1 polymorphisms and postmenopausal breast cancer stratified by smoking status.

From: A prospective study of XRCC1(X-ray cross-complementing group 1) polymorphisms and breast cancer risk

Polymorphism

Never smokers

Ever smokers

Arg194Trp

   Arg/Arg

No. of cases/no. of controls

217/237

216/175

ORa (95% CI)

1.00 (ref.)

1.00 (ref.)

   Arg/Trp or Trp/Trp

No. of cases/no. of controls

26/36

21/32

ORa (95% CI)

0.78 (0.43–1.40)

0.47 (0.24–0.94)

 

Interaction p = 0.28

Arg399Gln

   Arg/Arg

No. of cases/no. of controls

107/104

88/88

ORa (95% CI)

1.00 (ref.)

1.00 (ref.)

   Arg/Gln

No. of cases/no. of controls

100/112

92/89

ORa (95% CI)

0.91 (0.57–1.43)

1.06 (0.66–1.72)

   Gln/Gln

No. of cases/no. of controls

23/35

38/20

ORa (95% CI)

0.64 (0.33–1.26)

2.76 (1.36–5.63)

 

Interaction p = 0.01

  1. aMultivariate odds ratio and corresponding 95% confidence interval adjusted for: matched pairs, body mass index, age at menopause, age at menarche, alcohol intake, education, parity, age at first live birth, physical activity, history of breast cysts, family history of breast cancer in mother or sister, use of hormone replacement therapy, and smoking status. XRCC1, X-ray cross-complementing group 1.