A prospective study of XRCC1(X-ray cross-complementing group 1) polymorphisms and breast cancer risk

Breast Cancer Research

Table 1 Conditional logistic regression models examining the association between XRCC1 polymorphisms and postmenopausal breast cancer risk

Polymorphism	No. of cases	No. of controls	OR (95% CI)^a	OR (95% CI)^b
Arg194Trp (485 pairs)
Arg/Arg	437	415	1.00 (reference)	1.00 (reference)
Arg/Trp or Trp/Trp^c	48	70	0.66 (0.45–0.97)	0.62 (0.40–0.95)
Arg399Gln (452 pairs)
Arg/Arg	196	194	1.00 (reference)	1.00 (reference)
Arg/Gln	195	202	0.95 (0.71–1.27)	1.01 (0.73–1.39)
Gln/Gln	61	56	1.08 (0.71–1.63)	1.27 (0.79–2.02)
Arg/Gln or Gln/Gln	256	258	0.98 (0.75–1.28)	1.06 (0.78–1.44)

^aOdds ratio and corresponding 95% confidence interval adjusted for matched pairs; ^bmultivariate odds ratio and corresponding 95% confidence interval adjusted for: matched pairs, body mass index, age at menopause, age at menarche, alcohol intake, education, parity, age at first live birth, physical activity, history of breast cysts, family history of breast cancer in mother or sister, use of hormone replacement therapy, and smoking status; ^chomozygote TT group = one case and two controls. XRCC1, X-ray cross-complementing group 1.

ISSN: 1465-542X