Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

Table 4 Effects of dehydroepiandrosterone on p16 and p21 expression in mammary tumors (immunohistochemical assay)

Group	No. of animals	p16		P21
		Expression^a	p	Expression^a	p
Control	10	3.5 ± 2.2		5.6 ± 1.3
Dehydroepiandrosterone^b	8	6.3 ± 2.2	0.01	6.1 ± 1.2	n.s.

^ap16 and p21 values were generated semiquantitatively as described in the Materials and methods section; ^bdehydroepiandrosterone was given at 1,000 mg/kg.

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