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Table 4 Effects of dehydroepiandrosterone on p16 and p21 expression in mammary tumors (immunohistochemical assay)

From: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

Group No. of animals p16 P21
   Expressiona p Expressiona p
Control 10 3.5 ± 2.2   5.6 ± 1.3  
Dehydroepiandrosteroneb 8 6.3 ± 2.2 0.01 6.1 ± 1.2 n.s.
  1. ap16 and p21 values were generated semiquantitatively as described in the Materials and methods section; bdehydroepiandrosterone was given at 1,000 mg/kg.