Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

Table 3 Effects of DHEA and DHEA 8354 on the cell cycle phases (flow cytometry data)

Treatment	Dose (mg/kg diet)	No. of tumors	Phase of the cell cycle
			G1/G0 (%)	S (%)	G2M (%)
MNU	-	10	92.3 ± 0.8	5.4 ± 2.2	2.4 ± 1.1
DHEA	1,000	11	95.9 ± 1.8^a	1.8 ± 0.8^b	2.1 ± 1.5
DHEA 8354	1,000	14	94.8 ± 1.7^a	2.1 ± 1.0^b	2.3 ± 1.1

^a,bSignificant (p < 0.001) differences from control tumors. DHEA, dehydroepiandrosterone; MNU, N-nitroso-N-methylurea (mean ± SD) values.

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