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Table 3 Effects of DHEA and DHEA 8354 on the cell cycle phases (flow cytometry data)

From: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

Treatment Dose (mg/kg diet) No. of tumors Phase of the cell cycle
    G1/G0 (%) S (%) G2M (%)
MNU - 10 92.3 ± 0.8 5.4 ± 2.2 2.4 ± 1.1
DHEA 1,000 11 95.9 ± 1.8a 1.8 ± 0.8b 2.1 ± 1.5
DHEA 8354 1,000 14 94.8 ± 1.7a 2.1 ± 1.0b 2.3 ± 1.1
  1. a,bSignificant (p < 0.001) differences from control tumors. DHEA, dehydroepiandrosterone; MNU, N-nitroso-N-methylurea (mean ± SD) values.