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Table 2 Effects of DHEA and DHEA 8354 on SA-β-Gal cells, BrdU-labeled cells and apoptosis

From: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

Treatment Dose (mg/kg diet) No. of tumorsa SA-β-Gal cells (%) BrdU-labelled cells (%) Apoptosis (%)
Control 0 10 0.4 ± 0.2 15.6 ± 4.8 0.7 ± 0.4
DHEA 125 9 1.9 ± 1.8b 9.9 ± 4.2c 1.6 ± 0.4d
  1,000 15 3.3 ± 2.0b 2.2 ± 1.2c 3.2 ± 2.0d
DHEA 8354 125 8 0.7 ± 0.4 13.5 ± 4.4 1.1 ± 0.4
  1,000 10 2.8 ± 1.0b 5.3 ± 1.8c 1.5 ± 0.5d
  1. aOne tumor per animal was examined once; b,c,dthe differences in values between treated and control tumors are significant (p < 0.05; Student's t test). BrdU, bromodeoxyuridine; DHEA, dehydroepiandrosterone; SA-β-Gal, senescence-associated β-galactosidase (mean ± SD%) values.