Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

Table 1 Effects of dehydroepiandrosterone (DHEA) and DHEA 8354 on mammary tumor development

Treatment	Dose (mg/kg diet)	No. of animals	Weight of animals (g)	Tumor incidence (%)	Tumor multiplicity	Tumor (weight) burden (g)
Control	0	20	234	93.3	4.0	5.7
DHEA	125	29	231	96.7	3.2^a	3.7^b
	1,000	30	218	76.7	2.3^a	2.3^b
DHEA 8354	125	30	227	87.6	3.6	4.7
	1,000	29	222	100.0	3.4^a	2.6^b

^aSignificant difference for the frequency of tumors, DHEA (p < 0.01 and p < 0.001) and DHEA 8354 (p < 0.05). ^bSignificant difference for tumor weight/g (p < 0.01 and p < 0.01, DHEA and DHEA 8354, respectively) over the corresponding control (MNU-treated) groups.

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