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Table 1 Effects of dehydroepiandrosterone (DHEA) and DHEA 8354 on mammary tumor development

From: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism

Treatment Dose (mg/kg diet) No. of animals Weight of animals (g) Tumor incidence (%) Tumor multiplicity Tumor (weight) burden (g)
Control 0 20 234 93.3 4.0 5.7
DHEA 125 29 231 96.7 3.2a 3.7b
  1,000 30 218 76.7 2.3a 2.3b
DHEA 8354 125 30 227 87.6 3.6 4.7
  1,000 29 222 100.0 3.4a 2.6b
  1. aSignificant difference for the frequency of tumors, DHEA (p < 0.01 and p < 0.001) and DHEA 8354 (p < 0.05). bSignificant difference for tumor weight/g (p < 0.01 and p < 0.01, DHEA and DHEA 8354, respectively) over the corresponding control (MNU-treated) groups.